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Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function
Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer’s Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable benefits to the brains of offspring, suggesting that the physi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106691/ https://www.ncbi.nlm.nih.gov/pubmed/37077501 http://dx.doi.org/10.3389/fnagi.2023.1147420 |
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author | Kerr, Nathan R. Kelty, Taylor J. Mao, Xuansong Childs, Thomas E. Kline, David D. Rector, R. Scott Booth, Frank W. |
author_facet | Kerr, Nathan R. Kelty, Taylor J. Mao, Xuansong Childs, Thomas E. Kline, David D. Rector, R. Scott Booth, Frank W. |
author_sort | Kerr, Nathan R. |
collection | PubMed |
description | Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer’s Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable benefits to the brains of offspring, suggesting that the physical activity status of previous generations could play an important role in one’s brain health and their subsequent risk for neurodegenerative diseases. Thus, our study aimed to test the hypothesis that selective breeding for physical inactivity, or for high physical activity, preference produces heritable deficits and enhancements to brain health, respectively. To evaluate this hypothesis, male and female sedentary Low Voluntary Runners (LVR), wild type (WT), and High Voluntary Runner (HVR) rats underwent cognitive behavioral testing, analysis of hippocampal neurogenesis and mitochondrial respiration, and molecular analysis of the dentate gyrus. These analyses revealed that selecting for physical inactivity preference has produced major detriments to cognition, brain mitochondrial respiration, and neurogenesis in female LVR while female HVR display enhancements in brain glucose metabolism and hippocampal size. On the contrary, male LVR and HVR showed very few differences in these parameters relative to WT. Overall, we provide evidence that selective breeding for physical inactivity has a heritable and detrimental effect on brain health and that the female brain appears to be more susceptible to these effects. This emphasizes the importance of remaining physically active as chronic intergenerational physical inactivity likely increases susceptibility to neurodegenerative diseases for both the inactive individual and their offspring. |
format | Online Article Text |
id | pubmed-10106691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101066912023-04-18 Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function Kerr, Nathan R. Kelty, Taylor J. Mao, Xuansong Childs, Thomas E. Kline, David D. Rector, R. Scott Booth, Frank W. Front Aging Neurosci Aging Neuroscience Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer’s Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable benefits to the brains of offspring, suggesting that the physical activity status of previous generations could play an important role in one’s brain health and their subsequent risk for neurodegenerative diseases. Thus, our study aimed to test the hypothesis that selective breeding for physical inactivity, or for high physical activity, preference produces heritable deficits and enhancements to brain health, respectively. To evaluate this hypothesis, male and female sedentary Low Voluntary Runners (LVR), wild type (WT), and High Voluntary Runner (HVR) rats underwent cognitive behavioral testing, analysis of hippocampal neurogenesis and mitochondrial respiration, and molecular analysis of the dentate gyrus. These analyses revealed that selecting for physical inactivity preference has produced major detriments to cognition, brain mitochondrial respiration, and neurogenesis in female LVR while female HVR display enhancements in brain glucose metabolism and hippocampal size. On the contrary, male LVR and HVR showed very few differences in these parameters relative to WT. Overall, we provide evidence that selective breeding for physical inactivity has a heritable and detrimental effect on brain health and that the female brain appears to be more susceptible to these effects. This emphasizes the importance of remaining physically active as chronic intergenerational physical inactivity likely increases susceptibility to neurodegenerative diseases for both the inactive individual and their offspring. Frontiers Media S.A. 2023-04-03 /pmc/articles/PMC10106691/ /pubmed/37077501 http://dx.doi.org/10.3389/fnagi.2023.1147420 Text en Copyright © 2023 Kerr, Kelty, Mao, Childs, Kline, Rector and Booth. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Kerr, Nathan R. Kelty, Taylor J. Mao, Xuansong Childs, Thomas E. Kline, David D. Rector, R. Scott Booth, Frank W. Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function |
title | Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function |
title_full | Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function |
title_fullStr | Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function |
title_full_unstemmed | Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function |
title_short | Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function |
title_sort | selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106691/ https://www.ncbi.nlm.nih.gov/pubmed/37077501 http://dx.doi.org/10.3389/fnagi.2023.1147420 |
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