Cargando…

Selective breeding for physical inactivity produces cognitive deficits via altered hippocampal mitochondrial and synaptic function

Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer’s Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable benefits to the brains of offspring, suggesting that the physi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kerr, Nathan R., Kelty, Taylor J., Mao, Xuansong, Childs, Thomas E., Kline, David D., Rector, R. Scott, Booth, Frank W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106691/ https://www.ncbi.nlm.nih.gov/pubmed/37077501 http://dx.doi.org/10.3389/fnagi.2023.1147420

Ejemplares similares

Creatine Supplementation Upregulates mTORC1 Signaling and Markers of Synaptic Plasticity in the Dentate Gyrus While Ameliorating LPS-Induced Cognitive Impairment in Female Rats
por: Mao, Xuansong, et al.
Publicado: (2021)

Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats
por: Grigsby, Kolter B., et al.
Publicado: (2022)

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning
por: Sidlauskaite, Eva, et al.
Publicado: (2018)

Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity
por: Zhang, Haiwang, et al.
Publicado: (2022)

Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice
por: Nan, Xinyu, et al.
Publicado: (2022)

The Aged Lower Urinary Tract: Deficits in Neural Control Mechanisms
por: Hardy, Cara C.
Publicado: (2021)

Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice
por: Short, Annabel K., et al.
Publicado: (2022)

Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes
por: Lobon, Irene, et al.
Publicado: (2022)

Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling
por: Carbonell, Abigail U., et al.
Publicado: (2023)

Inhibiting amyloid beta (1–42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex
por: Olajide, Olayemi Joseph, et al.
Publicado: (2022)

Prohibitins in neurodegeneration and mitochondrial homeostasis
por: Fernandez-Abascal, Jesus, et al.
Publicado: (2022)

Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse
por: Stimmell, Alina C., et al.
Publicado: (2021)

Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases
por: Huynh, Van N, et al.
Publicado: (2021)

Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress
por: Ionescu-Tucker, Andra, et al.
Publicado: (2022)

Keeping the beat against time: Mitochondrial fitness in the aging heart
por: Mendoza, Arielys, et al.
Publicado: (2022)

Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction
por: Edling, Charlotte E., et al.
Publicado: (2019)

Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants
por: Traa, Annika, et al.
Publicado: (2023)

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons
por: Oettinghaus, B, et al.
Publicado: (2016)

Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy
por: Collins, Helen E., et al.
Publicado: (2021)

Obesity and Fatty Acids Promote Mitochondrial Translocation of STAT3 Through ROS-Dependent Mechanisms
por: Conway, Rachel, et al.
Publicado: (2022)

The C. elegans Observatory: High-throughput exploration of behavioral aging
por: Kerr, Rex A., et al.
Publicado: (2022)

Differential Effects of 2-Deoxyglucose and Glucose Deprivation on 4-Hydroxynonenal Dependent Mitochondrial Dysfunction in Primary Neurons
por: Dodson, Matthew, et al.
Publicado: (2022)

Editorial: Altered bioenergetics, mitochondrial quality control, and calcium signaling in the brain: Implications to age-related diseases
por: Soman, Smijin K., et al.
Publicado: (2023)

Editorial: Hippocampal mechanisms in aging and clinical memory decline
por: Ginsberg, Stephen D., et al.
Publicado: (2023)

Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction
por: Fan, Xing, et al.
Publicado: (2022)

Randomized Trial: D-Glyceric Acid Activates Mitochondrial Metabolism in 50–60-Year-Old Healthy Humans
por: Hirvonen, O. Petteri, et al.
Publicado: (2021)

Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8(+) EMRA T Cells During Type 2 Diabetes
por: Callender, Lauren A., et al.
Publicado: (2021)

Editorial: Improving memory deficits in Alzheimer's disease
por: Wang, Fushun, et al.
Publicado: (2022)

Lipocalin-2 Regulates Hippocampal Microglial Activation in Poststroke Depression
por: Wei, Li, et al.
Publicado: (2021)

Hippocampal microstructure, but not macrostructure, mediates age differences in episodic memory
por: Ibrahim, Kirolos, et al.
Publicado: (2023)

Signaling abnormality leading to excessive/aberrant synaptic plasticity in Alzheimer's disease
por: Kawabata, Shigeki
Publicado: (2022)

Anthracycline-induced cardiotoxicity and senescence
por: Booth, Laura K., et al.
Publicado: (2022)

Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer’s and Parkinson’s diseases
por: Nakamura, Tomohiro, et al.
Publicado: (2010)

Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans
por: Walsh, Kenneth, et al.
Publicado: (2022)

Classification of Alzheimer’s Disease Based on Abnormal Hippocampal Functional Connectivity and Machine Learning
por: Zhu, Qixiao, et al.
Publicado: (2022)

Altered hippocampal functional connectivity after the rupture of anterior communicating artery aneurysm
por: Chen, Fuxiang, et al.
Publicado: (2022)

Global trends and prospects about synaptic plasticity in Alzheimer’s disease: a bibliometric analysis
por: Zhang, Yingying, et al.
Publicado: (2023)

Hippocampal ischemia causes deficits in local field potential and synaptic plasticity
por: Wang, Shaoli, et al.
Publicado: (2015)

Serum cortisol is negatively related to hippocampal volume, brain structure, and memory performance in healthy aging and Alzheimer’s disease
por: Dronse, Julian, et al.
Publicado: (2023)

Structural brain signatures of frailty, defined as accumulation of self-reported health deficits in older adults
por: Gutiérrez-Zúñiga, Raquel, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_32f5le9qajog0ni1ufg24koeln