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Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

The vaginal microbiome is a distinct component of the human microbiome that is colonized by a wide variety of microorganisms. Lactobacilli are the most frequently identified microorganisms in the healthy human vagina. These Gram-positive bacilli can acidify the vaginal microenvironment, inhibit the...

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Detalles Bibliográficos
Autores principales: Liu, Peng, Lu, Yune, Li, Rongguo, Chen, Xiaodi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106725/
https://www.ncbi.nlm.nih.gov/pubmed/37077531
http://dx.doi.org/10.3389/fcimb.2023.1153894
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author Liu, Peng
Lu, Yune
Li, Rongguo
Chen, Xiaodi
author_facet Liu, Peng
Lu, Yune
Li, Rongguo
Chen, Xiaodi
author_sort Liu, Peng
collection PubMed
description The vaginal microbiome is a distinct component of the human microbiome that is colonized by a wide variety of microorganisms. Lactobacilli are the most frequently identified microorganisms in the healthy human vagina. These Gram-positive bacilli can acidify the vaginal microenvironment, inhibit the proliferation of other pathogenic microorganisms, and promote the maintenance of a eubiotic vaginal microbiome. However, a vaginal flora with a reduced proportion or abundance of lactobacilli is associated with various vaginal infections that have been linked to serious health consequences such as infertility, preterm birth, pelvic inflammatory disease, premature rupture of membranes, and miscarriage. Due to their “Generally Recognized as Safe” classification and critical role in vaginal health, probiotic lactobacilli have been widely used as an alternative or adjunct to traditional antibiotic therapy for the treatment of vaginal infections and restoration of the vaginal microbiome. This review focuses on the significant role of probiotic lactobacilli in the vaginal microenvironment and discusses the use of probiotic lactobacilli in the treatment of female vaginal infections in vitro and in vivo.
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spelling pubmed-101067252023-04-18 Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations Liu, Peng Lu, Yune Li, Rongguo Chen, Xiaodi Front Cell Infect Microbiol Cellular and Infection Microbiology The vaginal microbiome is a distinct component of the human microbiome that is colonized by a wide variety of microorganisms. Lactobacilli are the most frequently identified microorganisms in the healthy human vagina. These Gram-positive bacilli can acidify the vaginal microenvironment, inhibit the proliferation of other pathogenic microorganisms, and promote the maintenance of a eubiotic vaginal microbiome. However, a vaginal flora with a reduced proportion or abundance of lactobacilli is associated with various vaginal infections that have been linked to serious health consequences such as infertility, preterm birth, pelvic inflammatory disease, premature rupture of membranes, and miscarriage. Due to their “Generally Recognized as Safe” classification and critical role in vaginal health, probiotic lactobacilli have been widely used as an alternative or adjunct to traditional antibiotic therapy for the treatment of vaginal infections and restoration of the vaginal microbiome. This review focuses on the significant role of probiotic lactobacilli in the vaginal microenvironment and discusses the use of probiotic lactobacilli in the treatment of female vaginal infections in vitro and in vivo. Frontiers Media S.A. 2023-04-03 /pmc/articles/PMC10106725/ /pubmed/37077531 http://dx.doi.org/10.3389/fcimb.2023.1153894 Text en Copyright © 2023 Liu, Lu, Li and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Liu, Peng
Lu, Yune
Li, Rongguo
Chen, Xiaodi
Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations
title Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations
title_full Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations
title_fullStr Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations
title_full_unstemmed Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations
title_short Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations
title_sort use of probiotic lactobacilli in the treatment of vaginal infections: in vitro and in vivo investigations
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106725/
https://www.ncbi.nlm.nih.gov/pubmed/37077531
http://dx.doi.org/10.3389/fcimb.2023.1153894
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