PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspec...

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Detalles Bibliográficos
Autores principales: Shi, Chunxia, Cao, Pan, Wang, Yukun, Zhang, Qingqi, Zhang, Danmei, Wang, Yao, Wang, Luwen, Gong, Zuojiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106823/
https://www.ncbi.nlm.nih.gov/pubmed/37077221
http://dx.doi.org/10.2147/JIR.S403819
Descripción
Sumario:PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspective of PANoptosis, we focus on the relationship between pyroptosis, apoptosis and necroptosis, the key molecules in the process of PANoptosis and the formation of PANoptosome, as well as the role of PANoptosis in diseases. We aim to understand the mechanism of PANoptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases.

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