PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspec...

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Autores principales: Shi, Chunxia, Cao, Pan, Wang, Yukun, Zhang, Qingqi, Zhang, Danmei, Wang, Yao, Wang, Luwen, Gong, Zuojiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106823/
https://www.ncbi.nlm.nih.gov/pubmed/37077221
http://dx.doi.org/10.2147/JIR.S403819
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author Shi, Chunxia
Cao, Pan
Wang, Yukun
Zhang, Qingqi
Zhang, Danmei
Wang, Yao
Wang, Luwen
Gong, Zuojiong
author_facet Shi, Chunxia
Cao, Pan
Wang, Yukun
Zhang, Qingqi
Zhang, Danmei
Wang, Yao
Wang, Luwen
Gong, Zuojiong
author_sort Shi, Chunxia
collection PubMed
description PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspective of PANoptosis, we focus on the relationship between pyroptosis, apoptosis and necroptosis, the key molecules in the process of PANoptosis and the formation of PANoptosome, as well as the role of PANoptosis in diseases. We aim to understand the mechanism of PANoptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases.
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spelling pubmed-101068232023-04-18 PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis Shi, Chunxia Cao, Pan Wang, Yukun Zhang, Qingqi Zhang, Danmei Wang, Yao Wang, Luwen Gong, Zuojiong J Inflamm Res Review PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspective of PANoptosis, we focus on the relationship between pyroptosis, apoptosis and necroptosis, the key molecules in the process of PANoptosis and the formation of PANoptosome, as well as the role of PANoptosis in diseases. We aim to understand the mechanism of PANoptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases. Dove 2023-04-12 /pmc/articles/PMC10106823/ /pubmed/37077221 http://dx.doi.org/10.2147/JIR.S403819 Text en © 2023 Shi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Shi, Chunxia
Cao, Pan
Wang, Yukun
Zhang, Qingqi
Zhang, Danmei
Wang, Yao
Wang, Luwen
Gong, Zuojiong
PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
title PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
title_full PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
title_fullStr PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
title_full_unstemmed PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
title_short PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
title_sort panoptosis: a cell death characterized by pyroptosis, apoptosis, and necroptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106823/
https://www.ncbi.nlm.nih.gov/pubmed/37077221
http://dx.doi.org/10.2147/JIR.S403819
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