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Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
Tumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106871/ https://www.ncbi.nlm.nih.gov/pubmed/37089435 http://dx.doi.org/10.1186/s12645-023-00190-x |
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author | Sun, Weiwei Dai, Lili Cao, Yuqing Pan, Pengtao Zhi, Lijuan Wang, Xinke Yuan, Xinzhong Gao, Zi Guo, Sheng Liu, Guoyan Yin, Junlei Xie, Liangliang Wang, Liping Wang, Yanling Li, Wensheng Li, Hong Jia, Yunjie |
author_facet | Sun, Weiwei Dai, Lili Cao, Yuqing Pan, Pengtao Zhi, Lijuan Wang, Xinke Yuan, Xinzhong Gao, Zi Guo, Sheng Liu, Guoyan Yin, Junlei Xie, Liangliang Wang, Liping Wang, Yanling Li, Wensheng Li, Hong Jia, Yunjie |
author_sort | Sun, Weiwei |
collection | PubMed |
description | Tumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key chemotactic factor CCL2, which attracts monocytes to the vaccine injection site and enhances endocytosis of antigen. Monocytes subsequently enter the draining lymph node, and differentiate into monocyte-derived DCs (moDCs), which present tumor antigens to T lymphocytes and deliver a potent anti-tumor immune response. Mechanically, T-MPs activate the cGAS-STING signaling through DNA fragments, and then induce monocytes to upregulate the expression of IRF4, which is a key factor for monocyte differentiation into moDCs. More importantly, monocytes that have endocytosed T-MPs acquire the ability to treat tumors. Collectively, this work might provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12645-023-00190-x. |
format | Online Article Text |
id | pubmed-10106871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-101068712023-04-18 Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development Sun, Weiwei Dai, Lili Cao, Yuqing Pan, Pengtao Zhi, Lijuan Wang, Xinke Yuan, Xinzhong Gao, Zi Guo, Sheng Liu, Guoyan Yin, Junlei Xie, Liangliang Wang, Liping Wang, Yanling Li, Wensheng Li, Hong Jia, Yunjie Cancer Nanotechnol Research Tumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key chemotactic factor CCL2, which attracts monocytes to the vaccine injection site and enhances endocytosis of antigen. Monocytes subsequently enter the draining lymph node, and differentiate into monocyte-derived DCs (moDCs), which present tumor antigens to T lymphocytes and deliver a potent anti-tumor immune response. Mechanically, T-MPs activate the cGAS-STING signaling through DNA fragments, and then induce monocytes to upregulate the expression of IRF4, which is a key factor for monocyte differentiation into moDCs. More importantly, monocytes that have endocytosed T-MPs acquire the ability to treat tumors. Collectively, this work might provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12645-023-00190-x. Springer Vienna 2023-04-17 2023 /pmc/articles/PMC10106871/ /pubmed/37089435 http://dx.doi.org/10.1186/s12645-023-00190-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Sun, Weiwei Dai, Lili Cao, Yuqing Pan, Pengtao Zhi, Lijuan Wang, Xinke Yuan, Xinzhong Gao, Zi Guo, Sheng Liu, Guoyan Yin, Junlei Xie, Liangliang Wang, Liping Wang, Yanling Li, Wensheng Li, Hong Jia, Yunjie Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development |
title | Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development |
title_full | Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development |
title_fullStr | Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development |
title_full_unstemmed | Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development |
title_short | Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development |
title_sort | monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106871/ https://www.ncbi.nlm.nih.gov/pubmed/37089435 http://dx.doi.org/10.1186/s12645-023-00190-x |
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