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Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development

Tumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key...

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Autores principales: Sun, Weiwei, Dai, Lili, Cao, Yuqing, Pan, Pengtao, Zhi, Lijuan, Wang, Xinke, Yuan, Xinzhong, Gao, Zi, Guo, Sheng, Liu, Guoyan, Yin, Junlei, Xie, Liangliang, Wang, Liping, Wang, Yanling, Li, Wensheng, Li, Hong, Jia, Yunjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106871/
https://www.ncbi.nlm.nih.gov/pubmed/37089435
http://dx.doi.org/10.1186/s12645-023-00190-x
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author Sun, Weiwei
Dai, Lili
Cao, Yuqing
Pan, Pengtao
Zhi, Lijuan
Wang, Xinke
Yuan, Xinzhong
Gao, Zi
Guo, Sheng
Liu, Guoyan
Yin, Junlei
Xie, Liangliang
Wang, Liping
Wang, Yanling
Li, Wensheng
Li, Hong
Jia, Yunjie
author_facet Sun, Weiwei
Dai, Lili
Cao, Yuqing
Pan, Pengtao
Zhi, Lijuan
Wang, Xinke
Yuan, Xinzhong
Gao, Zi
Guo, Sheng
Liu, Guoyan
Yin, Junlei
Xie, Liangliang
Wang, Liping
Wang, Yanling
Li, Wensheng
Li, Hong
Jia, Yunjie
author_sort Sun, Weiwei
collection PubMed
description Tumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key chemotactic factor CCL2, which attracts monocytes to the vaccine injection site and enhances endocytosis of antigen. Monocytes subsequently enter the draining lymph node, and differentiate into monocyte-derived DCs (moDCs), which present tumor antigens to T lymphocytes and deliver a potent anti-tumor immune response. Mechanically, T-MPs activate the cGAS-STING signaling through DNA fragments, and then induce monocytes to upregulate the expression of IRF4, which is a key factor for monocyte differentiation into moDCs. More importantly, monocytes that have endocytosed T-MPs acquire the ability to treat tumors. Collectively, this work might provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12645-023-00190-x.
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spelling pubmed-101068712023-04-18 Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development Sun, Weiwei Dai, Lili Cao, Yuqing Pan, Pengtao Zhi, Lijuan Wang, Xinke Yuan, Xinzhong Gao, Zi Guo, Sheng Liu, Guoyan Yin, Junlei Xie, Liangliang Wang, Liping Wang, Yanling Li, Wensheng Li, Hong Jia, Yunjie Cancer Nanotechnol Research Tumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key chemotactic factor CCL2, which attracts monocytes to the vaccine injection site and enhances endocytosis of antigen. Monocytes subsequently enter the draining lymph node, and differentiate into monocyte-derived DCs (moDCs), which present tumor antigens to T lymphocytes and deliver a potent anti-tumor immune response. Mechanically, T-MPs activate the cGAS-STING signaling through DNA fragments, and then induce monocytes to upregulate the expression of IRF4, which is a key factor for monocyte differentiation into moDCs. More importantly, monocytes that have endocytosed T-MPs acquire the ability to treat tumors. Collectively, this work might provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12645-023-00190-x. Springer Vienna 2023-04-17 2023 /pmc/articles/PMC10106871/ /pubmed/37089435 http://dx.doi.org/10.1186/s12645-023-00190-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Sun, Weiwei
Dai, Lili
Cao, Yuqing
Pan, Pengtao
Zhi, Lijuan
Wang, Xinke
Yuan, Xinzhong
Gao, Zi
Guo, Sheng
Liu, Guoyan
Yin, Junlei
Xie, Liangliang
Wang, Liping
Wang, Yanling
Li, Wensheng
Li, Hong
Jia, Yunjie
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
title Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
title_full Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
title_fullStr Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
title_full_unstemmed Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
title_short Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
title_sort monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106871/
https://www.ncbi.nlm.nih.gov/pubmed/37089435
http://dx.doi.org/10.1186/s12645-023-00190-x
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