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Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats

INTRODUCTION: Previous studies in Ren-2 transgenic hypertensive rats (TGR) after 5/6 renal ablation (5/6 NX) have shown that besides pharmacological blockade of the renin-angiotensin system (RAS) also increasing kidney tissue epoxyeicosatrienoic acids (EET) levels by blocking soluble epoxide hydrola...

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Detalles Bibliográficos
Autores principales:	Chábová, Věra Čertíková, Kujal, Petr, Vaňourková, Zdeňka, Škaroupková, Petra, Sadowski, Janusz, Kompanowska-Jezierska, Elzbieta, Tesař, Vladimír, Hammock, Bruce, Imig, John, Maxová, Hana, Červenka, Luděk, Vaněčková, Ivana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107074/ https://www.ncbi.nlm.nih.gov/pubmed/31770762 http://dx.doi.org/10.1159/000504137

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