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Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review

Biomarkers associated with the development of comorbidities in atopic dermatitis (AD) patients have been reported, but have not yet been systematically reviewed. Seven electronic databases were searched, from database inception to September 2021. English language randomized controlled trials, prospe...

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Autores principales: Broderick, Conor, Ziehfreund, Stefanie, van Bart, Karin, Arents, Bernd, Eyerich, Kilian, Weidinger, Stephan, Rastrick, Joseph, Zink, Alexander, Flohr, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107168/
https://www.ncbi.nlm.nih.gov/pubmed/36366871
http://dx.doi.org/10.1111/all.15578
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author Broderick, Conor
Ziehfreund, Stefanie
van Bart, Karin
Arents, Bernd
Eyerich, Kilian
Weidinger, Stephan
Rastrick, Joseph
Zink, Alexander
Flohr, Carsten
author_facet Broderick, Conor
Ziehfreund, Stefanie
van Bart, Karin
Arents, Bernd
Eyerich, Kilian
Weidinger, Stephan
Rastrick, Joseph
Zink, Alexander
Flohr, Carsten
author_sort Broderick, Conor
collection PubMed
description Biomarkers associated with the development of comorbidities in atopic dermatitis (AD) patients have been reported, but have not yet been systematically reviewed. Seven electronic databases were searched, from database inception to September 2021. English language randomized controlled trials, prospective and retrospective cohort, and case–control studies that investigated the association between a biomarker and the development of comorbidities in AD patients were included. Two authors independently screened the records for eligibility, one extracted all data, and critically appraised the quality of studies and risk of bias. Fifty six articles met the inclusion criteria, evaluating 146 candidate biomarkers. The most frequently reported biomarkers were filaggrin mutations and allergen specific‐IgE. Promising biomarkers include specific‐IgE and/or skin prick tests predicting the development of asthma, and genetic polymorphisms predicting the occurrence of eczema herpeticum. The identified studies and biomarkers were highly heterogeneous, and associated with predominately moderate‐to‐high risk of bias across multiple domains. Overall, findings were inconsistent. High‐quality studies assessing biomarkers associated with the development of comorbidities in people with AD are lacking. Harmonized datasets and independent validation studies are urgently needed.
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spelling pubmed-101071682023-04-18 Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review Broderick, Conor Ziehfreund, Stefanie van Bart, Karin Arents, Bernd Eyerich, Kilian Weidinger, Stephan Rastrick, Joseph Zink, Alexander Flohr, Carsten Allergy Review Articles Biomarkers associated with the development of comorbidities in atopic dermatitis (AD) patients have been reported, but have not yet been systematically reviewed. Seven electronic databases were searched, from database inception to September 2021. English language randomized controlled trials, prospective and retrospective cohort, and case–control studies that investigated the association between a biomarker and the development of comorbidities in AD patients were included. Two authors independently screened the records for eligibility, one extracted all data, and critically appraised the quality of studies and risk of bias. Fifty six articles met the inclusion criteria, evaluating 146 candidate biomarkers. The most frequently reported biomarkers were filaggrin mutations and allergen specific‐IgE. Promising biomarkers include specific‐IgE and/or skin prick tests predicting the development of asthma, and genetic polymorphisms predicting the occurrence of eczema herpeticum. The identified studies and biomarkers were highly heterogeneous, and associated with predominately moderate‐to‐high risk of bias across multiple domains. Overall, findings were inconsistent. High‐quality studies assessing biomarkers associated with the development of comorbidities in people with AD are lacking. Harmonized datasets and independent validation studies are urgently needed. John Wiley and Sons Inc. 2022-12-08 2023-01 /pmc/articles/PMC10107168/ /pubmed/36366871 http://dx.doi.org/10.1111/all.15578 Text en © 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Broderick, Conor
Ziehfreund, Stefanie
van Bart, Karin
Arents, Bernd
Eyerich, Kilian
Weidinger, Stephan
Rastrick, Joseph
Zink, Alexander
Flohr, Carsten
Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review
title Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review
title_full Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review
title_fullStr Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review
title_full_unstemmed Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review
title_short Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: A systematic review
title_sort biomarkers associated with the development of comorbidities in patients with atopic dermatitis: a systematic review
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107168/
https://www.ncbi.nlm.nih.gov/pubmed/36366871
http://dx.doi.org/10.1111/all.15578
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