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Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition

Excessive genomic instability coupled with abnormalities in DNA repair pathways induces high levels of ‘replication stress’ when cancer cells propagate. Rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention towards targeting cell cycle checkpoint kin...

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Detalles Bibliográficos
Autores principales:	Sundararajan, Vignesh, Tan, Tuan Zea, Lim, Diana, Peng, Yanfen, Wengner, Antje Margret, Ngoi, Natalie Yan Li, Jeyasekharan, Anand D, Tan, David Shao Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107453/ https://www.ncbi.nlm.nih.gov/pubmed/36373784 http://dx.doi.org/10.1002/path.6032

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