Cargando…

Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data

This study evaluated drug–drug interactions (DDIs) between antibiotic and nonantibiotic drugs listed with warnings of severe outcomes in the British National Formulary based on adverse drug reaction (ADR) detectable with routine International Classification of Diseases, Tenth Revision coding. Data s...

Descripción completa

Detalles Bibliográficos
Autores principales: van Staa, Tjeerd Pieter, Pirmohamed, Munir, Sharma, Anita, Buchan, Iain, Ashcroft, Darren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107602/
https://www.ncbi.nlm.nih.gov/pubmed/36448824
http://dx.doi.org/10.1002/cpt.2807
_version_ 1785026642168512512
author van Staa, Tjeerd Pieter
Pirmohamed, Munir
Sharma, Anita
Buchan, Iain
Ashcroft, Darren M.
author_facet van Staa, Tjeerd Pieter
Pirmohamed, Munir
Sharma, Anita
Buchan, Iain
Ashcroft, Darren M.
author_sort van Staa, Tjeerd Pieter
collection PubMed
description This study evaluated drug–drug interactions (DDIs) between antibiotic and nonantibiotic drugs listed with warnings of severe outcomes in the British National Formulary based on adverse drug reaction (ADR) detectable with routine International Classification of Diseases, Tenth Revision coding. Data sources were Clinical Practice Research Databank GOLD and Aurum anonymized electronic health records from English general practices linked to hospital admission records. In propensity‐matched case‐control study, outcomes were ADR or emergency admissions. Analyzed were 121,546 ADR‐related admission cases matched to 638,238 controls. For most antibiotics, adjusted odds ratios (aORs) for ADR‐related hospital admission were large (aOR for trimethoprim 4.13; 95% confidence interval (CI), 3.97–4.30). Of the 51 DDIs evaluated for ADR‐related admissions, 38 DDIs (74.5%) had statistically increased aORs of concomitant exposure compared with nonexposure (mean aOR 3.96; range 1.59–11.42); for the 89 DDIs for emergency hospital admission, the results were 75 (84.3%) and mean aOR 2.40; range 1.43–4.17. Changing reference group to single antibiotic exposure reduced aORs for concomitant exposure by 76.5% and 83.0%, respectively. Medicines listed to cause nephrotoxicity substantially increased risks that were related to number of medicines (aOR was 2.55 (95% CI, 2.46–2.64) for current use of 1 and 10.44 (95% CI, 7.36–14.81) for 3 or more medicines). In conclusion, no evidence of substantial risk was found for multiple DDIs with antibiotics despite warnings of severe outcomes in a national formulary and flagging in electronic health record software. It is proposed that the evidence base for inclusion of DDIs in national formularies be strengthened and made publicly accessible and indiscriminate flagging, which compounds alert fatigue, be reduced.
format Online
Article
Text
id pubmed-10107602
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-101076022023-04-18 Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data van Staa, Tjeerd Pieter Pirmohamed, Munir Sharma, Anita Buchan, Iain Ashcroft, Darren M. Clin Pharmacol Ther Research This study evaluated drug–drug interactions (DDIs) between antibiotic and nonantibiotic drugs listed with warnings of severe outcomes in the British National Formulary based on adverse drug reaction (ADR) detectable with routine International Classification of Diseases, Tenth Revision coding. Data sources were Clinical Practice Research Databank GOLD and Aurum anonymized electronic health records from English general practices linked to hospital admission records. In propensity‐matched case‐control study, outcomes were ADR or emergency admissions. Analyzed were 121,546 ADR‐related admission cases matched to 638,238 controls. For most antibiotics, adjusted odds ratios (aORs) for ADR‐related hospital admission were large (aOR for trimethoprim 4.13; 95% confidence interval (CI), 3.97–4.30). Of the 51 DDIs evaluated for ADR‐related admissions, 38 DDIs (74.5%) had statistically increased aORs of concomitant exposure compared with nonexposure (mean aOR 3.96; range 1.59–11.42); for the 89 DDIs for emergency hospital admission, the results were 75 (84.3%) and mean aOR 2.40; range 1.43–4.17. Changing reference group to single antibiotic exposure reduced aORs for concomitant exposure by 76.5% and 83.0%, respectively. Medicines listed to cause nephrotoxicity substantially increased risks that were related to number of medicines (aOR was 2.55 (95% CI, 2.46–2.64) for current use of 1 and 10.44 (95% CI, 7.36–14.81) for 3 or more medicines). In conclusion, no evidence of substantial risk was found for multiple DDIs with antibiotics despite warnings of severe outcomes in a national formulary and flagging in electronic health record software. It is proposed that the evidence base for inclusion of DDIs in national formularies be strengthened and made publicly accessible and indiscriminate flagging, which compounds alert fatigue, be reduced. John Wiley and Sons Inc. 2022-12-16 /pmc/articles/PMC10107602/ /pubmed/36448824 http://dx.doi.org/10.1002/cpt.2807 Text en © 2022 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
van Staa, Tjeerd Pieter
Pirmohamed, Munir
Sharma, Anita
Buchan, Iain
Ashcroft, Darren M.
Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data
title Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data
title_full Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data
title_fullStr Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data
title_full_unstemmed Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data
title_short Clinical Relevance of Drug–Drug Interactions With Antibiotics as Listed in a National Medication Formulary: Results From Two Large Population‐Based Case‐Control Studies in Patients Aged 65–100 Years Using Linked English Primary Care and Hospital Data
title_sort clinical relevance of drug–drug interactions with antibiotics as listed in a national medication formulary: results from two large population‐based case‐control studies in patients aged 65–100 years using linked english primary care and hospital data
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107602/
https://www.ncbi.nlm.nih.gov/pubmed/36448824
http://dx.doi.org/10.1002/cpt.2807
work_keys_str_mv AT vanstaatjeerdpieter clinicalrelevanceofdrugdruginteractionswithantibioticsaslistedinanationalmedicationformularyresultsfromtwolargepopulationbasedcasecontrolstudiesinpatientsaged65100yearsusinglinkedenglishprimarycareandhospitaldata
AT pirmohamedmunir clinicalrelevanceofdrugdruginteractionswithantibioticsaslistedinanationalmedicationformularyresultsfromtwolargepopulationbasedcasecontrolstudiesinpatientsaged65100yearsusinglinkedenglishprimarycareandhospitaldata
AT sharmaanita clinicalrelevanceofdrugdruginteractionswithantibioticsaslistedinanationalmedicationformularyresultsfromtwolargepopulationbasedcasecontrolstudiesinpatientsaged65100yearsusinglinkedenglishprimarycareandhospitaldata
AT buchaniain clinicalrelevanceofdrugdruginteractionswithantibioticsaslistedinanationalmedicationformularyresultsfromtwolargepopulationbasedcasecontrolstudiesinpatientsaged65100yearsusinglinkedenglishprimarycareandhospitaldata
AT ashcroftdarrenm clinicalrelevanceofdrugdruginteractionswithantibioticsaslistedinanationalmedicationformularyresultsfromtwolargepopulationbasedcasecontrolstudiesinpatientsaged65100yearsusinglinkedenglishprimarycareandhospitaldata