In‐Plate Chemical Synthesis of Isopeptide‐Linked SUMOylated Peptide Fluorescence Polarization Reagents for High‐Throughput Screening of SENP Preferences

Small ubiquitin‐like modifiers (SUMOs) are conjugated to protein substrates in cells to regulate their function. The attachment of SUMO family members SUMO1‐3 to substrate proteins is reversed by specific isopeptidases called SENPs (sentrin‐specific protease). Whereas SENPs are SUMO‐isoform or linka...

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Detalles Bibliográficos
Autores principales: Huppelschoten, Yara, Mukhopadhyay, Rishov, Buchardt, Jens, Nielsen, Thomas E., Vertegaal, Alfred C. O., Ovaa, Huib, van der Heden van Noort, Gerbrand J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107784/
https://www.ncbi.nlm.nih.gov/pubmed/36377600
http://dx.doi.org/10.1002/cbic.202200601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107784/
https://www.ncbi.nlm.nih.gov/pubmed/36377600
http://dx.doi.org/10.1002/cbic.202200601

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