The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis

Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has been shown to involve several unusual enzymatic transformations. Using a combination of synthesis and in vitro assays we reveal that AbyV, a...

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Detalles Bibliográficos
Autores principales: Devine, Andrew J., Parnell, Alice E., Back, Catherine R., Lees, Nicholas R., Johns, Samuel T., Zulkepli, Ainul Z., Barringer, Rob, Zorn, Katja, Stach, James E. M., Crump, Matthew P., Hayes, Martin A., van der Kamp, Marc W., Race, Paul R., Willis, Christine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107801/
https://www.ncbi.nlm.nih.gov/pubmed/36314667
http://dx.doi.org/10.1002/anie.202213053

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