Cargando…

Synthesis and Biological Evaluation of C(13)/C(13′)‐Bis(desmethyl)disorazole Z

We describe the total synthesis of the macrodiolide C(13)/C(13′)‐bis(desmethyl)disorazole Z through double inter‐/intramolecular Stille cross‐coupling of a monomeric vinyl stannane/vinyl iodide precursor to form the macrocycle. The key step in the synthesis of this precursor was a stereoselective al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bold, Christian Paul, Lucena‐Agell, Daniel, Oliva, María Ángela, Díaz, José Fernando, Altmann, Karl‐Heinz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107878/ https://www.ncbi.nlm.nih.gov/pubmed/36281761 http://dx.doi.org/10.1002/anie.202212190

Ejemplares similares

Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C(1)
por: Speed, Alexander W. H., et al.
Publicado: (2014)

Extending the Structure‐Activity Relationship of Disorazole C(1): Exchanging the Oxazole Ring by Thiazole and Influence of Chiral Centers within the Disorazole Core on Cytotoxicity
por: Lizzadro, Luca, et al.
Publicado: (2022)

Gymnodimine A and 13-desMethyl Spirolide C Alter Intracellular Calcium Levels via Acetylcholine Receptors
por: Nieva, Joyce A., et al.
Publicado: (2020)

Enzymatic Biotransformation of 13-desmethyl Spirolide C by Two Infaunal Mollusk Species: The Limpet Patella vulgata and the Cockle Cerastoderma edule
por: Rossignoli, Araceli E., et al.
Publicado: (2022)

Spirolides in Bivalve Mollusk of the Galician (NW Spain) Coast: Interspecific, Spatial, Temporal Variation and Presence of an Isomer of 13-Desmethyl Spirolide C
por: Blanco, Juan, et al.
Publicado: (2022)

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C(1)
por: Xu, Fengfeng L, et al.
Publicado: (2010)

Bis-cyclopropane analog of disorazole C(1) is a microtubule-destabilizing agent active in abcb1-overexpressing human colon cancer cells
por: Wu, Shaoyu, et al.
Publicado: (2015)

Self-Assembly of Disorazole C(1) through a One-Pot Alkyne Metathesis Homodimerization Strategy**
por: Ralston, Kevin J, et al.
Publicado: (2015)

Self‐Assembly of Disorazole C(1) through a One‐Pot Alkyne Metathesis Homodimerization Strategy
por: Ralston, Kevin J., et al.
Publicado: (2015)

The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression
por: Gao, Yunsheng, et al.
Publicado: (2023)

Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering
por: Tu, Qiang, et al.
Publicado: (2016)

Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins
por: Primdahl, Karoline G., et al.
Publicado: (2016)

Low (13)C-(13)C abundances in abiotic ethane
por: Taguchi, Koudai, et al.
Publicado: (2022)

(Z,Z)-1,4-Diiodo-1,4-bis(trimethylsilyl)buta-1,3-diene
por: Bats, Jan W., et al.
Publicado: (2008)

Determination of Olanzapine and N-desmethyl-olanzapine in Plasma Using a Reversed-Phase HPLC Coupled with Coulochemical Detection: Correlation of Olanzapine or N-desmethyl-olanzapine Concentration with Metabolic Parameters
por: Lu, Mong-Liang, et al.
Publicado: (2013)

THE BIOSYNTHESIS OF C(13) COMPOUNDS : I. THE BIOSYNTHESIS OF C(13)-LABELED STARCH
por: Livingston, L. G., et al.
Publicado: (1947)

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin
por: Menchon, Grégory, et al.
Publicado: (2018)

Synthesis, FTIR, (13)C-NMR and Temperature-Dependent (1)HNMR Characteristics of Bis-naphthalimide Derivatives
por: Grzesiak, Waldemar, et al.
Publicado: (2012)

Radiosynthesis and in vivo evaluation of (11)C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors
por: Kawamura, Kazunori, et al.
Publicado: (2019)

Nukleonen-Transfer am Beispiel der $^{13}$C($^{13}$C, $^{12}$C) $^{14}$C-Reaktionen
por: Könnecke, R
Publicado: (1982)

The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats
por: Liu, Xian-yun, et al.
Publicado: (2013)

Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline
por: Ding, Yangming, et al.
Publicado: (2023)

[μ-1,3-Dioxo-1,3-bis(pyridin-2-yl)propane-2,2-diido-κ(2) N,C (2):κ(2) C (2),N′]bis[(1,3-diphenylpropane-1,3-dionato-κ(2) O,O′)palladium(II)](Pd—Pd)
por: Maggini, Simona, et al.
Publicado: (2011)

Uptake/Efflux Transport of Tramadol Enantiomers and O-Desmethyl-Tramadol: Focus on P-Glycoprotein
por: Kanaan, Mouna, et al.
Publicado: (2009)

Pharmacodynamics and Pharmacokinetics of Injectable Pimobendan and Its Metabolite, O-Desmethyl-Pimobendan, in Healthy Dogs
por: Pichayapaiboon, Poonavit, et al.
Publicado: (2021)

A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses
por: SASAKI, Naoki, et al.
Publicado: (2009)

Multisite Kinetic Modeling of (13)C Metabolic MR Using [1-(13)C]Pyruvate
por: Gómez Damián, Pedro A., et al.
Publicado: (2014)

Asymmetric Synthesis of (−)-6-Desmethyl-Fluvirucinine A(1) via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions
por: Moon, Hyunyoung, et al.
Publicado: (2018)

PHIP hyperpolarized [1-(13)C]pyruvate and [1-(13)C]acetate esters via PH-INEPT polarization transfer monitored by (13)C NMR and MRI
por: Svyatova, Alexandra, et al.
Publicado: (2021)

p(13)CMFA: Parsimonious (13)C metabolic flux analysis
por: Foguet, Carles, et al.
Publicado: (2019)

Structural insight into the stabilization of microtubules by taxanes
por: Prota, Andrea E, et al.
Publicado: (2023)

(2)H,(13)C-Cholesterol for Dynamics and Structural Studies of Biological Membranes
por: Borcik, Collin G., et al.
Publicado: (2022)

A Comparison of (13)C-Methacetin and (13)C-Octanoate Breath Test for the Evaluation of Nonalcoholic Steatohepatitis
por: Fierbinteanu-Braticevici, Carmen, et al.
Publicado: (2023)

Application of Plasma Levels of Olanzapine and N-Desmethyl-Olanzapine to Monitor Clinical Efficacy in Patients with Schizophrenia
por: Lu, Mong-Liang, et al.
Publicado: (2016)

Pharmacokinetics of Pimobendan and Its Metabolite O-Desmethyl-Pimobendan Following Rectal Administration to Healthy Dogs
por: Her, Jiwoong, et al.
Publicado: (2020)

Relationship Between Plasma Olanzapine and N-Desmethyl-Olanzapine Concentration and Metabolic Parameters in Patients With Schizophrenia
por: An, Huimei, et al.
Publicado: (2022)

Synthesis, Characterization, and In Vivo Evaluation of Desmethyl Anethole Trithione Phosphate Prodrug for Ameliorating Cerebral Ischemia-Reperfusion Injury in Rats
por: Huang, Sheng, et al.
Publicado: (2020)

Bis(1,3-dimethyl-1,3-diazinan-2-one)dinitratodioxidouranium(VI)
por: Suzuki, Tomoya, et al.
Publicado: (2010)

Bis[2-(1,3-benzothiazol-2-yl)phenyl-κ(2) C (1),N][1,3-bis(4-bromophenyl)propane-1,3-dionato-κ(2) O,O′]iridium(III)
por: Kim, Young-Inn, et al.
Publicado: (2013)

13C-NMR of natural products
por: Rahman, Atta-ur-, 1942-
Publicado: (1992)

Cannot write session to /tmp/vufind_sessions/sess_1tm5ju1drbgpr0utevvjoaakep