Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B

AIMS: Primary head/neck mucosal melanomas (MMs) are rare and exhibit aggressive biologic behaviour and elevated mutational loads. The molecular mechanisms responsible for high genomic instability observed in head/neck MMs remain elusive. The DNA cytosine deaminase APOBEC3B (A3B) constitutes a major...

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Detalles Bibliográficos
Autores principales: Argyris, Prokopios P, Naumann, Jordan, Jarvis, Matthew C, Wilkinson, Peter E, Ho, Dan P, Islam, Mohammed N, Bhattacharyya, Indraneel, Gopalakrishnan, Rajaram, Li, Faqian, Koutlas, Ioannis G, Giubellino, Alessio, Harris, Reuben S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107945/
https://www.ncbi.nlm.nih.gov/pubmed/36416305
http://dx.doi.org/10.1111/his.14843

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