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The role of O-GlcNAcylation in development
O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled t...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108035/ https://www.ncbi.nlm.nih.gov/pubmed/36924340 http://dx.doi.org/10.1242/dev.201370 |
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| author | Czajewski, Ignacy van Aalten, Daan M. F. |
| author_facet | Czajewski, Ignacy van Aalten, Daan M. F. |
| author_sort | Czajewski, Ignacy |
| collection | PubMed |
| description | O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis. |
| format | Online Article Text |
| id | pubmed-10108035 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | The Company of Biologists Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101080352023-04-18 The role of O-GlcNAcylation in development Czajewski, Ignacy van Aalten, Daan M. F. Development Primer O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis. The Company of Biologists Ltd 2023-03-16 /pmc/articles/PMC10108035/ /pubmed/36924340 http://dx.doi.org/10.1242/dev.201370 Text en © 2023. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| spellingShingle | Primer Czajewski, Ignacy van Aalten, Daan M. F. The role of O-GlcNAcylation in development |
| title | The role of O-GlcNAcylation in development |
| title_full | The role of O-GlcNAcylation in development |
| title_fullStr | The role of O-GlcNAcylation in development |
| title_full_unstemmed | The role of O-GlcNAcylation in development |
| title_short | The role of O-GlcNAcylation in development |
| title_sort | role of o-glcnacylation in development |
| topic | Primer |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108035/ https://www.ncbi.nlm.nih.gov/pubmed/36924340 http://dx.doi.org/10.1242/dev.201370 |
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