Cargando…

Memory CD8(+) T cells upregulate glycolysis and effector functions under limiting oxygen conditions

Memory CD8(+) T cells are indispensable for maintaining long‐term immunity against intracellular pathogens and tumors. Despite their presence at oxygen‐deprived infected tissue sites or in tumors, the impact of local oxygen pressure on memory CD8(+) T cells remains largely unclear. We sought to eluc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beumer‐Chuwonpad, Ammarina, van Alphen, Floris P.J., Kragten, Natasja A.M., Freen‐van Heeren, Julian J., Rodriguez Gomez, Maria, Verhoeven, Arthur J., van den Biggelaar, Maartje, van Gisbergen, Klaas P.J.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Adaptive immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108084/ https://www.ncbi.nlm.nih.gov/pubmed/36482267 http://dx.doi.org/10.1002/eji.202249918

Ejemplares similares

Hobit and Blimp‐1 regulate T(RM) abundance after LCMV infection by suppressing tissue exit pathways of T(RM)precursors
por: Parga‐Vidal, Loreto, et al.
Publicado: (2022)

Human T cells employ conserved AU‐rich elements to fine‐tune IFN‐γ production
por: Freen‐van Heeren, Julian J., et al.
Publicado: (2020)

Hobit and Blimp‐1 instruct the differentiation of iNKT cells into resident‐phenotype lymphocytes after lineage commitment
por: Kragten, Natasja AM, et al.
Publicado: (2022)

The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer
por: Beumer-Chuwonpad, Ammarina, et al.
Publicado: (2021)

BAFF augments IgA2 and IL‐10 production by TLR7/8 stimulated total peripheral blood B cells
por: den Hartog, Gerco, et al.
Publicado: (2017)

Curtailed T‐cell activation curbs effector differentiation and generates CD8(+) T cells with a naturally‐occurring memory stem cell phenotype
por: Zanon, Veronica, et al.
Publicado: (2017)

GPA33 is expressed on multiple human blood cell types and distinguishes CD4(+) central memory T cells with and without effector function
por: Opstelten, Rianne, et al.
Publicado: (2021)

Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8(+) T‐cell populations in humans
por: Remmerswaal, Ester B. M., et al.
Publicado: (2019)

Expression of heavy chain‐only antibodies can support B‐cell development in light chain knockout chickens
por: Schusser, Benjamin, et al.
Publicado: (2016)

High‐throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells
por: Tuijnenburg, Paul, et al.
Publicado: (2019)

Natural T‐cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles
por: Kremer, Anita N., et al.
Publicado: (2018)

Reduced TCR‐dependent activation through citrullination of a T‐cell epitope enhances Th17 development by disruption of the STAT3/5 balance
por: Tibbitt, Christopher, et al.
Publicado: (2016)

Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells
por: Behr, Felix M., et al.
Publicado: (2018)

Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function
por: Popović, Branka, et al.
Publicado: (2023)

Retinoic Acid Signaling Is Required for Dendritic Cell Maturation and the Induction of T Cell Immunity
por: Farazuddin, Mohammad, et al.
Publicado: (2023)

CD5 levels define functionally heterogeneous populations of naïve human CD4(+) T cells
por: Sood, Aditi, et al.
Publicado: (2021)

Mouse Memory CD8 T Cell Subsets Defined by Tissue-Resident Memory Integrin Expression Exhibit Distinct Metabolic Profiles
por: Sportiello, Mike, et al.
Publicado: (2023)

Super‐killer CTLs are generated by single gene deletion of Bach2
por: Barton, Philippa R., et al.
Publicado: (2022)

TIM‐3 and CEACAM1 do not interact in cis and in trans
por: De Sousa Linhares, Annika, et al.
Publicado: (2020)

Polypyrimidine tract binding protein 1 regulates the activation of mouse CD8 T cells
por: D'Angeli, Vanessa, et al.
Publicado: (2022)

PD-1 Impairs CD8(+) T Cell Granzyme B Production in Aged Mice during Acute Viral Respiratory Infection
por: Parks, Olivia B., et al.
Publicado: (2023)

A Nasal Inflammatory Cytokine Signature Is Associated with Early Graft-versus-Host Disease of the Lung after Allogeneic Hematopoietic Cell Transplantation: Proof of Concept
por: Ostrin, Edwin J., et al.
Publicado: (2023)

Murine CD8 T‐cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density
por: Gilfillan, Connie B., et al.
Publicado: (2019)

PD‐1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state
por: Mair, Iris, et al.
Publicado: (2018)

T cell receptor alpha variable 12‐2 bias in the immunodominant response to Yellow fever virus
por: Bovay, Amandine, et al.
Publicado: (2017)

IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
por: Yánez, Diana C., et al.
Publicado: (2018)

Monocytes mediate Salmonella Typhimurium‐induced tumor growth inhibition in a mouse melanoma model
por: Johnson, Síle A., et al.
Publicado: (2021)

Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12
por: Komai-Koma, Mousa, et al.
Publicado: (2016)

Scarcity of autoreactive human blood IgA(+) memory B cells
por: Prigent, Julie, et al.
Publicado: (2016)

Maintenance of CD8(+) memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation
por: Siracusa, Francesco, et al.
Publicado: (2017)

Sustained cross‐presentation capacity of murine splenic dendritic cell subsets in vivo
por: Ho, Nataschja I., et al.
Publicado: (2018)

Retention of Ag‐specific memory CD4(+) T cells in the draining lymph node indicates lymphoid tissue resident memory populations
por: Marriott, Clare L., et al.
Publicado: (2017)

“Inflamm‐aging” influences immune cell survival factors in human bone marrow
por: Pangrazzi, Luca, et al.
Publicado: (2017)

Multifunctional cytokine production reveals functional superiority of memory CD4 T cells
por: Westerhof, Lotus M, et al.
Publicado: (2019)

Divergent memory responses driven by adenoviral vectors are impacted by epitope competition
por: Colston, Julia M, et al.
Publicado: (2019)

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8(+) T cells
por: Pangrazzi, Luca, et al.
Publicado: (2019)

Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice
por: Paiva, Ricardo S., et al.
Publicado: (2021)

HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis
por: Spagnuolo, Lorenzo, et al.
Publicado: (2021)

Autophagy regulates long‐term cross‐presentation by murine dendritic cells
por: Ho, Nataschja I., et al.
Publicado: (2021)

Flow cytometry‐based high‐throughput RNAi screening for miRNAs regulating MHC class II HLA‐DR surface expression
por: Houseman, Maja, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5ighk6t8jcknd3d871p5dtsqu2