Cargando…
Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex
Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long‐lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. Several prior studies have revealed that PSE associates with a...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108202/ https://www.ncbi.nlm.nih.gov/pubmed/36458867 http://dx.doi.org/10.1111/ejn.15882 |
_version_ | 1785026799591227392 |
---|---|
author | Rajasilta, Olli Häkkinen, Suvi Björnsdotter, Malin Scheinin, Noora M. Lehtola, Satu J. Saunavaara, Jani Parkkola, Riitta Lähdesmäki, Tuire Karlsson, Linnea Karlsson, Hasse Tuulari, Jetro J. |
author_facet | Rajasilta, Olli Häkkinen, Suvi Björnsdotter, Malin Scheinin, Noora M. Lehtola, Satu J. Saunavaara, Jani Parkkola, Riitta Lähdesmäki, Tuire Karlsson, Linnea Karlsson, Hasse Tuulari, Jetro J. |
author_sort | Rajasilta, Olli |
collection | PubMed |
description | Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long‐lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. Several prior studies have revealed that PSE associates with alterations in neonate functional connectivity in the prefrontal regions and amygdala. In this study, we explored whether maternal psychological symptoms measured during the 24th gestational week had associations with neonate resting‐state network metrics. Twenty‐one neonates (nine female) underwent resting‐state fMRI scanning (mean gestation‐corrected age at scan 26.95 days) to assess fractional amplitude of low‐frequency fluctuation (fALFF) and regional homogeneity (ReHo). The ReHo/fALFF maps were used in multiple regression analysis to investigate whether maternal self‐reported anxiety and/or depressive symptoms associate with neonate functional brain features. Maternal psychological distress (composite score of depressive and anxiety symptoms) was positively associated with fALFF in the neonate medial prefrontal cortex (mPFC). Anxiety and depressive symptoms, assessed separately, exhibited similar but weaker associations. Post hoc seed‐based connectivity analyses further showed that distal connectivity of mPFC covaried with PSE. No associations were found between neonate ReHo and PSE. These results offer preliminary evidence that PSE may affect functional features of the developing brain during gestation. |
format | Online Article Text |
id | pubmed-10108202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101082022023-04-18 Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex Rajasilta, Olli Häkkinen, Suvi Björnsdotter, Malin Scheinin, Noora M. Lehtola, Satu J. Saunavaara, Jani Parkkola, Riitta Lähdesmäki, Tuire Karlsson, Linnea Karlsson, Hasse Tuulari, Jetro J. Eur J Neurosci Behavioral Neuroscience Prenatal stress exposure (PSE) has been observed to exert a programming effect on the developing infant brain, possibly with long‐lasting consequences on temperament, cognitive functions and the risk for developing psychiatric disorders. Several prior studies have revealed that PSE associates with alterations in neonate functional connectivity in the prefrontal regions and amygdala. In this study, we explored whether maternal psychological symptoms measured during the 24th gestational week had associations with neonate resting‐state network metrics. Twenty‐one neonates (nine female) underwent resting‐state fMRI scanning (mean gestation‐corrected age at scan 26.95 days) to assess fractional amplitude of low‐frequency fluctuation (fALFF) and regional homogeneity (ReHo). The ReHo/fALFF maps were used in multiple regression analysis to investigate whether maternal self‐reported anxiety and/or depressive symptoms associate with neonate functional brain features. Maternal psychological distress (composite score of depressive and anxiety symptoms) was positively associated with fALFF in the neonate medial prefrontal cortex (mPFC). Anxiety and depressive symptoms, assessed separately, exhibited similar but weaker associations. Post hoc seed‐based connectivity analyses further showed that distal connectivity of mPFC covaried with PSE. No associations were found between neonate ReHo and PSE. These results offer preliminary evidence that PSE may affect functional features of the developing brain during gestation. John Wiley and Sons Inc. 2022-12-17 2023-01 /pmc/articles/PMC10108202/ /pubmed/36458867 http://dx.doi.org/10.1111/ejn.15882 Text en © 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Behavioral Neuroscience Rajasilta, Olli Häkkinen, Suvi Björnsdotter, Malin Scheinin, Noora M. Lehtola, Satu J. Saunavaara, Jani Parkkola, Riitta Lähdesmäki, Tuire Karlsson, Linnea Karlsson, Hasse Tuulari, Jetro J. Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex |
title | Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex |
title_full | Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex |
title_fullStr | Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex |
title_full_unstemmed | Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex |
title_short | Maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex |
title_sort | maternal psychological distress associates with alterations in resting‐state low‐frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108202/ https://www.ncbi.nlm.nih.gov/pubmed/36458867 http://dx.doi.org/10.1111/ejn.15882 |
work_keys_str_mv | AT rajasiltaolli maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT hakkinensuvi maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT bjornsdottermalin maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT scheininnooram maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT lehtolasatuj maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT saunavaarajani maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT parkkolariitta maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT lahdesmakituire maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT karlssonlinnea maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT karlssonhasse maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex AT tuularijetroj maternalpsychologicaldistressassociateswithalterationsinrestingstatelowfrequencyfluctuationsanddistalfunctionalconnectivityoftheneonatemedialprefrontalcortex |