Chronic acidosis rewires cancer cell metabolism through PPARα signaling

The mechanisms linking tumor microenvironment acidosis to disease progression are not understood. Here, we used mammary, pancreatic, and colon cancer cells to show that adaptation to growth at an extracellular pH (pH( e )) mimicking acidic tumor niches is associated with upregulated net acid extrusi...

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Detalles Bibliográficos
Autores principales: Rolver, Michala G., Holland, Lya K. K., Ponniah, Muthulakshmi, Prasad, Nanditha S., Yao, Jiayi, Schnipper, Julie, Kramer, Signe, Elingaard‐Larsen, Line, Pedraz‐Cuesta, Elena, Liu, Bin, Pardo, Luis A., Maeda, Kenji, Sandelin, Albin, Pedersen, Stine Falsig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Molecular Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108231/
https://www.ncbi.nlm.nih.gov/pubmed/36533672
http://dx.doi.org/10.1002/ijc.34404

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