Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with minimal treatment options and a global rise in prevalence. PDAC is characterized by frequent driver mutations including KRAS and TP53 (p53), and a dense, acidic tumor microenvironment (TME). The relation between genot...

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Detalles Bibliográficos
Autores principales: Czaplinska, Dominika, Ialchina, Renata, Andersen, Henriette Berg, Yao, Jiayi, Stigliani, Arnaud, Dannesboe, Johs, Flinck, Mette, Chen, Xiaoming, Mitrega, Jakub, Gnosa, Sebastian Peter, Dmytriyeva, Oksana, Alves, Frauke, Napp, Joanna, Sandelin, Albin, Pedersen, Stine Falsig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Molecular Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108304/
https://www.ncbi.nlm.nih.gov/pubmed/36408933
http://dx.doi.org/10.1002/ijc.34367

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