Pan‐HSP90 ligand binding reveals isoform‐specific differences in plasticity and water networks

Isoforms of heat shock protein 90 (HSP90) fold oncoproteins that facilitate all 10 hallmarks of cancer. However, its promise as a therapeutic target remains unfulfilled as there is still no FDA‐approved drug targeting HSP90 in disease. Among the reasons hindering progress are side effects caused by...

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Detalles Bibliográficos
Autores principales: Stachowski, Timothy R., Nithianantham, Stanley, Vanarotti, Murugendra, Lopez, Karlo, Fischer, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108437/
https://www.ncbi.nlm.nih.gov/pubmed/36938943
http://dx.doi.org/10.1002/pro.4629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108437/
https://www.ncbi.nlm.nih.gov/pubmed/36938943
http://dx.doi.org/10.1002/pro.4629

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