Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy

BACKGROUND: KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnesylation and geranylgeranylation upstream that are activated upon mutated KRAS....

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Detalles Bibliográficos
Autores principales: Tsubaki, Masanobu, Takeda, Tomoya, Matsuda, Takuya, Kishimoto, Kana, Takefuji, Honoka, Taniwaki, Yuzuki, Ueda, Misa, Hoshida, Tadafumi, Tanabe, Kazufumi, Nishida, Shozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108455/
https://www.ncbi.nlm.nih.gov/pubmed/37069612
http://dx.doi.org/10.1186/s12935-023-02884-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108455/
https://www.ncbi.nlm.nih.gov/pubmed/37069612
http://dx.doi.org/10.1186/s12935-023-02884-z

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