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Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy

BACKGROUND: KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnesylation and geranylgeranylation upstream that are activated upon mutated KRAS....

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Detalles Bibliográficos
Autores principales:	Tsubaki, Masanobu, Takeda, Tomoya, Matsuda, Takuya, Kishimoto, Kana, Takefuji, Honoka, Taniwaki, Yuzuki, Ueda, Misa, Hoshida, Tadafumi, Tanabe, Kazufumi, Nishida, Shozo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108455/ https://www.ncbi.nlm.nih.gov/pubmed/37069612 http://dx.doi.org/10.1186/s12935-023-02884-z

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