A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example

BACKGROUND: The oral bioavailability and blood–brain barrier permeability of many herbal products are too low to explain the significant efficacy fully. Gut microbiota and liver can metabolize herbal ingredients to more absorbable forms. The current study aims to evaluate the ability of a novel biot...

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Detalles Bibliográficos
Autores principales: Hu, En, Li, Zhilin, Li, Teng, Yang, Xueping, Ding, Ruoqi, Jiang, Haoying, Su, Hong, Cheng, Menghan, Yu, Zhe, Li, Haigang, Tang, Tao, Wang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108474/
https://www.ncbi.nlm.nih.gov/pubmed/37069580
http://dx.doi.org/10.1186/s13020-023-00745-5

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