Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab

An 81-year-old woman was referred to nephrology for a follow-up on progressive chronic kidney disease. She has a past medical history of hypertension, T2DM, breast cancer, and secondary hyperparathyroidism related to renal disease. A renal biopsy showed patchy interstitial fibrosis and tubular atrop...

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Detalles Bibliográficos
Autores principales: Nguyen, Tien, Brodsky, Sergey, Maroz, Natallia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108657/
https://www.ncbi.nlm.nih.gov/pubmed/37077588
http://dx.doi.org/10.7759/cureus.36327
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author Nguyen, Tien
Brodsky, Sergey
Maroz, Natallia
author_facet Nguyen, Tien
Brodsky, Sergey
Maroz, Natallia
author_sort Nguyen, Tien
collection PubMed
description An 81-year-old woman was referred to nephrology for a follow-up on progressive chronic kidney disease. She has a past medical history of hypertension, T2DM, breast cancer, and secondary hyperparathyroidism related to renal disease. A renal biopsy showed patchy interstitial fibrosis and tubular atrophy with an increased number of IgG4-positive plasma cells. A diagnosis of IgG4-related kidney disease was made based on clinical presentation and pathology. The patient ultimately required the initiation of hemodialysis, despite the administration of steroids and rituximab.
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spelling pubmed-101086572023-04-18 Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab Nguyen, Tien Brodsky, Sergey Maroz, Natallia Cureus Internal Medicine An 81-year-old woman was referred to nephrology for a follow-up on progressive chronic kidney disease. She has a past medical history of hypertension, T2DM, breast cancer, and secondary hyperparathyroidism related to renal disease. A renal biopsy showed patchy interstitial fibrosis and tubular atrophy with an increased number of IgG4-positive plasma cells. A diagnosis of IgG4-related kidney disease was made based on clinical presentation and pathology. The patient ultimately required the initiation of hemodialysis, despite the administration of steroids and rituximab. Cureus 2023-03-18 /pmc/articles/PMC10108657/ /pubmed/37077588 http://dx.doi.org/10.7759/cureus.36327 Text en Copyright © 2023, Nguyen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Nguyen, Tien
Brodsky, Sergey
Maroz, Natallia
Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
title Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
title_full Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
title_fullStr Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
title_full_unstemmed Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
title_short Progression to End-Stage Renal Disease Due to IgG4-Related Nephritis Refractory to Rituximab
title_sort progression to end-stage renal disease due to igg4-related nephritis refractory to rituximab
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108657/
https://www.ncbi.nlm.nih.gov/pubmed/37077588
http://dx.doi.org/10.7759/cureus.36327
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