Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer’s disease

A series of OA-tacrine hybrids with the alkylamine linker was designed, synthesized, and evaluated as effective cholinesterase inhibitors for the treatment of Alzheimer’s disease (AD). Biological activity results demonstrated that some hybrids possessed significant inhibitory activities against acet...

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Detalles Bibliográficos
Autores principales: Yang, Huali, Jia, Hongwei, Deng, Minghui, Zhang, Kaicheng, Liu, Yaoyang, Liu, Yang, Cheng, Maosheng, Xiao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108742/
https://www.ncbi.nlm.nih.gov/pubmed/36950955
http://dx.doi.org/10.1080/14756366.2023.2192439

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