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Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study

Digital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we evaluated whether a smartwatch and smartphone applicati...

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Autores principales: Adams, Jamie L., Kangarloo, Tairmae, Tracey, Brian, O’Donnell, Patricio, Volfson, Dmitri, Latzman, Robert D., Zach, Neta, Alexander, Robert, Bergethon, Peter, Cosman, Joshua, Anderson, David, Best, Allen, Severson, Joan, Kostrzebski, Melissa A., Auinger, Peggy, Wilmot, Peter, Pohlson, Yvonne, Waddell, Emma, Jensen-Roberts, Stella, Gong, Yishu, Kilambi, Krishna Praneeth, Herrero, Teresa Ruiz, Ray Dorsey, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108794/
https://www.ncbi.nlm.nih.gov/pubmed/37069193
http://dx.doi.org/10.1038/s41531-023-00497-x
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author Adams, Jamie L.
Kangarloo, Tairmae
Tracey, Brian
O’Donnell, Patricio
Volfson, Dmitri
Latzman, Robert D.
Zach, Neta
Alexander, Robert
Bergethon, Peter
Cosman, Joshua
Anderson, David
Best, Allen
Severson, Joan
Kostrzebski, Melissa A.
Auinger, Peggy
Wilmot, Peter
Pohlson, Yvonne
Waddell, Emma
Jensen-Roberts, Stella
Gong, Yishu
Kilambi, Krishna Praneeth
Herrero, Teresa Ruiz
Ray Dorsey, E.
author_facet Adams, Jamie L.
Kangarloo, Tairmae
Tracey, Brian
O’Donnell, Patricio
Volfson, Dmitri
Latzman, Robert D.
Zach, Neta
Alexander, Robert
Bergethon, Peter
Cosman, Joshua
Anderson, David
Best, Allen
Severson, Joan
Kostrzebski, Melissa A.
Auinger, Peggy
Wilmot, Peter
Pohlson, Yvonne
Waddell, Emma
Jensen-Roberts, Stella
Gong, Yishu
Kilambi, Krishna Praneeth
Herrero, Teresa Ruiz
Ray Dorsey, E.
author_sort Adams, Jamie L.
collection PubMed
description Digital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we evaluated whether a smartwatch and smartphone application could measure features of early PD. 82 individuals with early, untreated PD and 50 age-matched controls wore research-grade sensors, a smartwatch, and a smartphone while performing standardized assessments in the clinic. At home, participants wore the smartwatch for seven days after each clinic visit and completed motor, speech and cognitive tasks on the smartphone every other week. Features derived from the devices, particularly arm swing, the proportion of time with tremor, and finger tapping, differed significantly between individuals with early PD and age-matched controls and had variable correlation with traditional assessments. Longitudinal assessments will inform the value of these digital measures for use in future clinical trials.
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spelling pubmed-101087942023-04-18 Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study Adams, Jamie L. Kangarloo, Tairmae Tracey, Brian O’Donnell, Patricio Volfson, Dmitri Latzman, Robert D. Zach, Neta Alexander, Robert Bergethon, Peter Cosman, Joshua Anderson, David Best, Allen Severson, Joan Kostrzebski, Melissa A. Auinger, Peggy Wilmot, Peter Pohlson, Yvonne Waddell, Emma Jensen-Roberts, Stella Gong, Yishu Kilambi, Krishna Praneeth Herrero, Teresa Ruiz Ray Dorsey, E. NPJ Parkinsons Dis Article Digital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we evaluated whether a smartwatch and smartphone application could measure features of early PD. 82 individuals with early, untreated PD and 50 age-matched controls wore research-grade sensors, a smartwatch, and a smartphone while performing standardized assessments in the clinic. At home, participants wore the smartwatch for seven days after each clinic visit and completed motor, speech and cognitive tasks on the smartphone every other week. Features derived from the devices, particularly arm swing, the proportion of time with tremor, and finger tapping, differed significantly between individuals with early PD and age-matched controls and had variable correlation with traditional assessments. Longitudinal assessments will inform the value of these digital measures for use in future clinical trials. Nature Publishing Group UK 2023-04-17 /pmc/articles/PMC10108794/ /pubmed/37069193 http://dx.doi.org/10.1038/s41531-023-00497-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Adams, Jamie L.
Kangarloo, Tairmae
Tracey, Brian
O’Donnell, Patricio
Volfson, Dmitri
Latzman, Robert D.
Zach, Neta
Alexander, Robert
Bergethon, Peter
Cosman, Joshua
Anderson, David
Best, Allen
Severson, Joan
Kostrzebski, Melissa A.
Auinger, Peggy
Wilmot, Peter
Pohlson, Yvonne
Waddell, Emma
Jensen-Roberts, Stella
Gong, Yishu
Kilambi, Krishna Praneeth
Herrero, Teresa Ruiz
Ray Dorsey, E.
Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study
title Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study
title_full Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study
title_fullStr Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study
title_full_unstemmed Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study
title_short Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study
title_sort using a smartwatch and smartphone to assess early parkinson’s disease in the watch-pd study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108794/
https://www.ncbi.nlm.nih.gov/pubmed/37069193
http://dx.doi.org/10.1038/s41531-023-00497-x
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