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Targeting IL-6 trans-signalling: past, present and future prospects

Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory conditions and cancer. Classical IL-6 signalling involves the binding of IL-6 to the membrane-bound IL-6 receptor α-subunit (hereafter termed...

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Detalles Bibliográficos
Autores principales:	Rose-John, Stefan, Jenkins, Brendan J., Garbers, Christoph, Moll, Jens M., Scheller, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108826/ https://www.ncbi.nlm.nih.gov/pubmed/37069261 http://dx.doi.org/10.1038/s41577-023-00856-y

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