The novel estrogen receptor modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer’s disease

Based on previous evidence that the non-steroidal estrogen receptor modulator STX mitigates the effects of neurotoxic Amyloid-β (Aβ) in vitro, we have evaluated its neuroprotective benefits in a mouse model of Alzheimer’s disease. Cohorts of 5XFAD mice, which begin to accumulate cerebral Aβ at two m...

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Detalles Bibliográficos
Autores principales: Quinn, Joseph F., Kelly, Martin J., Harris, Christopher J., Hack, Wyatt, Gray, Nora E., Kulik, Veronika, Bostick, Zoe, Brumbach, Barbara H., Copenhaver, Philip F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108899/
https://www.ncbi.nlm.nih.gov/pubmed/36209948
http://dx.doi.org/10.1016/j.nbd.2022.105888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108899/
https://www.ncbi.nlm.nih.gov/pubmed/36209948
http://dx.doi.org/10.1016/j.nbd.2022.105888

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