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P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study
INTRODUCTION: The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) remains uncertain. This study examined cross-sectional associations between sleep spindle metrics and cognitive function outcomes in community-dwelling...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109179/ http://dx.doi.org/10.1093/sleepadvances/zpab014.153 |
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author | Parker, J Melaku, Y D’Rozario, A Wittert, G Martin, S Catcheside, P Lechat, B Teare, A Appleton, S Adams, R Vakulin, A |
author_facet | Parker, J Melaku, Y D’Rozario, A Wittert, G Martin, S Catcheside, P Lechat, B Teare, A Appleton, S Adams, R Vakulin, A |
author_sort | Parker, J |
collection | PubMed |
description | INTRODUCTION: The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) remains uncertain. This study examined cross-sectional associations between sleep spindle metrics and cognitive function outcomes in community-dwelling men. METHODS: Men, Androgen, Inflammation, Lifestyle, Environment, and Stress (MAILES) study participants (n=477) underwent home-based polysomnography between 2010–2011 and completed the inspection time task, trail-making test A (TMT-A) and B (TMT-B), and Fuld object memory evaluation. Frontal spindle metrics derived from sleep electroencephalography included occurrence (total no. of sleep spindle events) and slow (11–13 Hz) and fast (13–16 Hz) spindle density (no./min) during N2 and N3 sleep. RESULTS: Men with OSA (any OSA and severe OSA) had significantly impaired sleep spindles (reduced occurrence and densities). In the complete study sample, higher spindle occurrence during N2 sleep was independently associated with faster inspection time (B= -0.44, 95% CI [-0.87, -0.02], p=0.041), whereas higher fast spindle density during N3 sleep was independently associated with worse TMT-B performance (B=20.7, 95% CI [0.55, 40.9], p=0.044). Furthermore, in men with severe OSA (apnea-hypopnea index ≥30/h), higher slow spindle density during N2 sleep was independently associated with worse TMT-A and TMT-B performance, whereas only higher spindle occurrence during N2 sleep was independently associated with worse TMT-A performance (all p<0.05). DISCUSSION: Specific spindle metrics during N2 and N3 sleep are independently associated with cognitive function in an unselected population of men and men with undiagnosed severe OSA. The utility of sleep spindles for predicting cognitive dysfunction and decline requires further investigation. |
format | Online Article Text |
id | pubmed-10109179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101091792023-05-15 P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study Parker, J Melaku, Y D’Rozario, A Wittert, G Martin, S Catcheside, P Lechat, B Teare, A Appleton, S Adams, R Vakulin, A Sleep Adv Poster Presentations INTRODUCTION: The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) remains uncertain. This study examined cross-sectional associations between sleep spindle metrics and cognitive function outcomes in community-dwelling men. METHODS: Men, Androgen, Inflammation, Lifestyle, Environment, and Stress (MAILES) study participants (n=477) underwent home-based polysomnography between 2010–2011 and completed the inspection time task, trail-making test A (TMT-A) and B (TMT-B), and Fuld object memory evaluation. Frontal spindle metrics derived from sleep electroencephalography included occurrence (total no. of sleep spindle events) and slow (11–13 Hz) and fast (13–16 Hz) spindle density (no./min) during N2 and N3 sleep. RESULTS: Men with OSA (any OSA and severe OSA) had significantly impaired sleep spindles (reduced occurrence and densities). In the complete study sample, higher spindle occurrence during N2 sleep was independently associated with faster inspection time (B= -0.44, 95% CI [-0.87, -0.02], p=0.041), whereas higher fast spindle density during N3 sleep was independently associated with worse TMT-B performance (B=20.7, 95% CI [0.55, 40.9], p=0.044). Furthermore, in men with severe OSA (apnea-hypopnea index ≥30/h), higher slow spindle density during N2 sleep was independently associated with worse TMT-A and TMT-B performance, whereas only higher spindle occurrence during N2 sleep was independently associated with worse TMT-A performance (all p<0.05). DISCUSSION: Specific spindle metrics during N2 and N3 sleep are independently associated with cognitive function in an unselected population of men and men with undiagnosed severe OSA. The utility of sleep spindles for predicting cognitive dysfunction and decline requires further investigation. Oxford University Press 2021-10-07 /pmc/articles/PMC10109179/ http://dx.doi.org/10.1093/sleepadvances/zpab014.153 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Sleep Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Poster Presentations Parker, J Melaku, Y D’Rozario, A Wittert, G Martin, S Catcheside, P Lechat, B Teare, A Appleton, S Adams, R Vakulin, A P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study |
title | P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study |
title_full | P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study |
title_fullStr | P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study |
title_full_unstemmed | P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study |
title_short | P110 The association between sleep spindles and cognitive function in middle-aged and older men: A community-based study |
title_sort | p110 the association between sleep spindles and cognitive function in middle-aged and older men: a community-based study |
topic | Poster Presentations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109179/ http://dx.doi.org/10.1093/sleepadvances/zpab014.153 |
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