Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity

Adequate thymidylate [deoxythymidine monophosphate (dTMP) or the “T” base in DNA] levels are essential for stability of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA). Folate and vitamin B12 (B12) are essential cofactors in folate-mediated one-carbon metabolism (FOCM), a metabolic network which su...

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Detalles Bibliográficos
Autores principales: Heyden, Katarina E, Fiddler, Joanna L, Xiu, Yuwen, Malysheva, Olga V, Handzlik, Michal K, Phinney, Whitney N, Stiles, Linsey, Stabler, Sally P, Metallo, Christian M, Caudill, Marie A, Field, Martha S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109189/
https://www.ncbi.nlm.nih.gov/pubmed/37077889
http://dx.doi.org/10.1093/pnasnexus/pgad105

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