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O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome

BACKGROUND: Autonomic dysfunction has been implicated in the pathophysiology of Sudden Infant Death Syndrome (SIDS). Butyrylcholinesterase (BChE) is an enzyme of the cholinergic system, a major branch of the autonomic system, and may provide a measure of autonomic (dys)function. This study was under...

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Autores principales: Harrington, C, Al Hafid, N, Waters, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109202/
http://dx.doi.org/10.1093/sleepadvances/zpac029.032
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author Harrington, C
Al Hafid, N
Waters, K
author_facet Harrington, C
Al Hafid, N
Waters, K
author_sort Harrington, C
collection PubMed
description BACKGROUND: Autonomic dysfunction has been implicated in the pathophysiology of Sudden Infant Death Syndrome (SIDS). Butyrylcholinesterase (BChE) is an enzyme of the cholinergic system, a major branch of the autonomic system, and may provide a measure of autonomic (dys)function. This study was undertaken to evaluate BChE in infants and young children who had died from SIDS or Sudden Unexpected Death. METHODS: We measured BChE specific activity (BChEsa) in the eluate of 5μL spots punched from the dried blood spots (DBS) taken at birth as part of the newborn screening program. Results for each of 67 SUDI deaths classified by the coroner (aged 1 week – 104 weeks) = Cases, were compared to 10 date of birth - and gender-matched surviving controls (Controls), with five cases reclassified to meet criteria for SIDS. FINDINGS: Conditional logistic regression showed that in groups where cases were reported as “SIDS death” there was strong evidence that lower BChEsa was associated with death (OR=0·73 per U/mg, 95% CI 0·60 – 0·89, P=0·0014), whereas in the “Non-SIDS death” group there was no evidence of a linear association between BChEsa and death (OR=1·001 per U/mg, 95% CI 0·89 – 1·13, P=0·99). CONCLUSION: BChEsa, measured in DBS taken 2-3 days after birth, was lower in babies who subsequently died of SIDS compared to surviving controls and other Non-SIDS deaths. We conclude that a previously unidentified cholinergic deficit, identifiable by abnormal BChEsa, is present at birth in SIDS babies and represents a measurable, specific vulnerability prior to their death.
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spelling pubmed-101092022023-05-15 O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome Harrington, C Al Hafid, N Waters, K Sleep Adv Oral Presentations BACKGROUND: Autonomic dysfunction has been implicated in the pathophysiology of Sudden Infant Death Syndrome (SIDS). Butyrylcholinesterase (BChE) is an enzyme of the cholinergic system, a major branch of the autonomic system, and may provide a measure of autonomic (dys)function. This study was undertaken to evaluate BChE in infants and young children who had died from SIDS or Sudden Unexpected Death. METHODS: We measured BChE specific activity (BChEsa) in the eluate of 5μL spots punched from the dried blood spots (DBS) taken at birth as part of the newborn screening program. Results for each of 67 SUDI deaths classified by the coroner (aged 1 week – 104 weeks) = Cases, were compared to 10 date of birth - and gender-matched surviving controls (Controls), with five cases reclassified to meet criteria for SIDS. FINDINGS: Conditional logistic regression showed that in groups where cases were reported as “SIDS death” there was strong evidence that lower BChEsa was associated with death (OR=0·73 per U/mg, 95% CI 0·60 – 0·89, P=0·0014), whereas in the “Non-SIDS death” group there was no evidence of a linear association between BChEsa and death (OR=1·001 per U/mg, 95% CI 0·89 – 1·13, P=0·99). CONCLUSION: BChEsa, measured in DBS taken 2-3 days after birth, was lower in babies who subsequently died of SIDS compared to surviving controls and other Non-SIDS deaths. We conclude that a previously unidentified cholinergic deficit, identifiable by abnormal BChEsa, is present at birth in SIDS babies and represents a measurable, specific vulnerability prior to their death. Oxford University Press 2022-11-09 /pmc/articles/PMC10109202/ http://dx.doi.org/10.1093/sleepadvances/zpac029.032 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Sleep Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Oral Presentations
Harrington, C
Al Hafid, N
Waters, K
O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome
title O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome
title_full O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome
title_fullStr O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome
title_full_unstemmed O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome
title_short O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome
title_sort o033 butyrylcholinesterase is a potential biomarker for sudden infant death syndrome
topic Oral Presentations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109202/
http://dx.doi.org/10.1093/sleepadvances/zpac029.032
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