Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD)

The mortality rates of individuals with myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are currently unknown. This study aimed to assess the mortality rate in a large cohort of patients with MOGAD. Since none of the patients in our cohort died, we estimated the upper limit of a 95% con...

Descripción completa

Detalles Bibliográficos
Autores principales: Lotan, Itay, Romanow, Gabriela, Salky, Rebecca, Molazadeh, Negar, Vishnevetsky, Anastasia, Anderson, Monique, Bilodeau, Philippe Antoine, Cutter, Gary, Levy, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109314/
https://www.ncbi.nlm.nih.gov/pubmed/36852731
http://dx.doi.org/10.1002/acn3.51750
_version_ 1785027037110468608
author Lotan, Itay
Romanow, Gabriela
Salky, Rebecca
Molazadeh, Negar
Vishnevetsky, Anastasia
Anderson, Monique
Bilodeau, Philippe Antoine
Cutter, Gary
Levy, Michael
author_facet Lotan, Itay
Romanow, Gabriela
Salky, Rebecca
Molazadeh, Negar
Vishnevetsky, Anastasia
Anderson, Monique
Bilodeau, Philippe Antoine
Cutter, Gary
Levy, Michael
author_sort Lotan, Itay
collection PubMed
description The mortality rates of individuals with myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are currently unknown. This study aimed to assess the mortality rate in a large cohort of patients with MOGAD. Since none of the patients in our cohort died, we estimated the upper limit of a 95% confidence interval of the crude mortality rate in the cohort to be 2.1%. These data suggest that mortality in MOGAD is lower than that reported in other neuroinflammatory diseases and comparable to the age‐adjusted mortality rates of the general population in the United States. Additional studies are warranted to confirm this observation.
format Online
Article
Text
id pubmed-10109314
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-101093142023-04-18 Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD) Lotan, Itay Romanow, Gabriela Salky, Rebecca Molazadeh, Negar Vishnevetsky, Anastasia Anderson, Monique Bilodeau, Philippe Antoine Cutter, Gary Levy, Michael Ann Clin Transl Neurol Brief Communications The mortality rates of individuals with myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are currently unknown. This study aimed to assess the mortality rate in a large cohort of patients with MOGAD. Since none of the patients in our cohort died, we estimated the upper limit of a 95% confidence interval of the crude mortality rate in the cohort to be 2.1%. These data suggest that mortality in MOGAD is lower than that reported in other neuroinflammatory diseases and comparable to the age‐adjusted mortality rates of the general population in the United States. Additional studies are warranted to confirm this observation. John Wiley and Sons Inc. 2023-02-28 /pmc/articles/PMC10109314/ /pubmed/36852731 http://dx.doi.org/10.1002/acn3.51750 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Lotan, Itay
Romanow, Gabriela
Salky, Rebecca
Molazadeh, Negar
Vishnevetsky, Anastasia
Anderson, Monique
Bilodeau, Philippe Antoine
Cutter, Gary
Levy, Michael
Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD)
title Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD)
title_full Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD)
title_fullStr Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD)
title_full_unstemmed Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD)
title_short Low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (MOGAD)
title_sort low mortality rate in a large cohort of myelin oligodendrocyte glycoprotein antibody disease (mogad)
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109314/
https://www.ncbi.nlm.nih.gov/pubmed/36852731
http://dx.doi.org/10.1002/acn3.51750
work_keys_str_mv AT lotanitay lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT romanowgabriela lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT salkyrebecca lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT molazadehnegar lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT vishnevetskyanastasia lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT andersonmonique lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT bilodeauphilippeantoine lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT cuttergary lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad
AT levymichael lowmortalityrateinalargecohortofmyelinoligodendrocyteglycoproteinantibodydiseasemogad

Ejemplares similares