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Corneal nerve loss predicts dementia in patients with mild cognitive impairment

OBJECTIVES: This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). METHODS: Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain vo...

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Autores principales: Ponirakis, Georgios, Al Hamad, Hanadi, Omar, Dunya A. M., Petropoulos, Ioannis N., Khan, Adnan, Gad, Hoda, Chandran, Mani, Gadelseed, Masharig, Elsotouhy, Ahmed, Ramadan, Marwan, Gawhale, Priya V., Elorrabi, Marwa, Tosino, Rhia, Mahfoud, Ziyad R., Khan, Shafi, Manikoth, Pravija, Abdelrahim, Yasmin H. M., Refaee, Mahmoud A., Thodi, Noushad, Own, Ahmed, Shuaib, Ashfaq, Malik, Rayaz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109317/
https://www.ncbi.nlm.nih.gov/pubmed/36852724
http://dx.doi.org/10.1002/acn3.51747
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author Ponirakis, Georgios
Al Hamad, Hanadi
Omar, Dunya A. M.
Petropoulos, Ioannis N.
Khan, Adnan
Gad, Hoda
Chandran, Mani
Gadelseed, Masharig
Elsotouhy, Ahmed
Ramadan, Marwan
Gawhale, Priya V.
Elorrabi, Marwa
Tosino, Rhia
Mahfoud, Ziyad R.
Khan, Shafi
Manikoth, Pravija
Abdelrahim, Yasmin H. M.
Refaee, Mahmoud A.
Thodi, Noushad
Own, Ahmed
Shuaib, Ashfaq
Malik, Rayaz A.
author_facet Ponirakis, Georgios
Al Hamad, Hanadi
Omar, Dunya A. M.
Petropoulos, Ioannis N.
Khan, Adnan
Gad, Hoda
Chandran, Mani
Gadelseed, Masharig
Elsotouhy, Ahmed
Ramadan, Marwan
Gawhale, Priya V.
Elorrabi, Marwa
Tosino, Rhia
Mahfoud, Ziyad R.
Khan, Shafi
Manikoth, Pravija
Abdelrahim, Yasmin H. M.
Refaee, Mahmoud A.
Thodi, Noushad
Own, Ahmed
Shuaib, Ashfaq
Malik, Rayaz A.
author_sort Ponirakis, Georgios
collection PubMed
description OBJECTIVES: This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). METHODS: Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia. RESULTS: Of 107 participants with MCI aged 68.4 ± 7.7 years, 33 (30.8%) progressed to dementia over 2.6‐years of follow‐up. Compared to participants with NCI (n = 12), participants who remained with MCI (n = 74) or progressed to dementia had lower corneal nerve measures (p < 0.0001). Progressors had lower corneal nerve measures, hippocampal, and whole brain volume (all p < 0.0001). However, CCM had a higher prognostic accuracy (72%–75% vs 68%–69%) for identifying individuals who progressed to dementia compared to hippocampus and whole brain volume. The adjusted odds ratio for progression to dementia was 6.1 (95% CI: 1.6–23.8) and 4.1 (95% CI: 1.2–14.2) higher with abnormal CCM measures, but was not significant for abnormal brain volume. INTERPRETATION: Abnormal CCM measures have a higher prognostic accuracy than brain volumetry for predicting progression from MCI to dementia. Further work is required to validate the predictive ability of CCM compared to other established biomarkers of dementia.
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spelling pubmed-101093172023-04-18 Corneal nerve loss predicts dementia in patients with mild cognitive impairment Ponirakis, Georgios Al Hamad, Hanadi Omar, Dunya A. M. Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Chandran, Mani Gadelseed, Masharig Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Tosino, Rhia Mahfoud, Ziyad R. Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Refaee, Mahmoud A. Thodi, Noushad Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. Ann Clin Transl Neurol Research Articles OBJECTIVES: This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). METHODS: Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia. RESULTS: Of 107 participants with MCI aged 68.4 ± 7.7 years, 33 (30.8%) progressed to dementia over 2.6‐years of follow‐up. Compared to participants with NCI (n = 12), participants who remained with MCI (n = 74) or progressed to dementia had lower corneal nerve measures (p < 0.0001). Progressors had lower corneal nerve measures, hippocampal, and whole brain volume (all p < 0.0001). However, CCM had a higher prognostic accuracy (72%–75% vs 68%–69%) for identifying individuals who progressed to dementia compared to hippocampus and whole brain volume. The adjusted odds ratio for progression to dementia was 6.1 (95% CI: 1.6–23.8) and 4.1 (95% CI: 1.2–14.2) higher with abnormal CCM measures, but was not significant for abnormal brain volume. INTERPRETATION: Abnormal CCM measures have a higher prognostic accuracy than brain volumetry for predicting progression from MCI to dementia. Further work is required to validate the predictive ability of CCM compared to other established biomarkers of dementia. John Wiley and Sons Inc. 2023-02-28 /pmc/articles/PMC10109317/ /pubmed/36852724 http://dx.doi.org/10.1002/acn3.51747 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ponirakis, Georgios
Al Hamad, Hanadi
Omar, Dunya A. M.
Petropoulos, Ioannis N.
Khan, Adnan
Gad, Hoda
Chandran, Mani
Gadelseed, Masharig
Elsotouhy, Ahmed
Ramadan, Marwan
Gawhale, Priya V.
Elorrabi, Marwa
Tosino, Rhia
Mahfoud, Ziyad R.
Khan, Shafi
Manikoth, Pravija
Abdelrahim, Yasmin H. M.
Refaee, Mahmoud A.
Thodi, Noushad
Own, Ahmed
Shuaib, Ashfaq
Malik, Rayaz A.
Corneal nerve loss predicts dementia in patients with mild cognitive impairment
title Corneal nerve loss predicts dementia in patients with mild cognitive impairment
title_full Corneal nerve loss predicts dementia in patients with mild cognitive impairment
title_fullStr Corneal nerve loss predicts dementia in patients with mild cognitive impairment
title_full_unstemmed Corneal nerve loss predicts dementia in patients with mild cognitive impairment
title_short Corneal nerve loss predicts dementia in patients with mild cognitive impairment
title_sort corneal nerve loss predicts dementia in patients with mild cognitive impairment
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109317/
https://www.ncbi.nlm.nih.gov/pubmed/36852724
http://dx.doi.org/10.1002/acn3.51747
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