Cargando…
Corneal nerve loss predicts dementia in patients with mild cognitive impairment
OBJECTIVES: This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). METHODS: Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain vo...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109317/ https://www.ncbi.nlm.nih.gov/pubmed/36852724 http://dx.doi.org/10.1002/acn3.51747 |
_version_ | 1785027037850763264 |
---|---|
author | Ponirakis, Georgios Al Hamad, Hanadi Omar, Dunya A. M. Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Chandran, Mani Gadelseed, Masharig Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Tosino, Rhia Mahfoud, Ziyad R. Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Refaee, Mahmoud A. Thodi, Noushad Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. |
author_facet | Ponirakis, Georgios Al Hamad, Hanadi Omar, Dunya A. M. Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Chandran, Mani Gadelseed, Masharig Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Tosino, Rhia Mahfoud, Ziyad R. Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Refaee, Mahmoud A. Thodi, Noushad Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. |
author_sort | Ponirakis, Georgios |
collection | PubMed |
description | OBJECTIVES: This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). METHODS: Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia. RESULTS: Of 107 participants with MCI aged 68.4 ± 7.7 years, 33 (30.8%) progressed to dementia over 2.6‐years of follow‐up. Compared to participants with NCI (n = 12), participants who remained with MCI (n = 74) or progressed to dementia had lower corneal nerve measures (p < 0.0001). Progressors had lower corneal nerve measures, hippocampal, and whole brain volume (all p < 0.0001). However, CCM had a higher prognostic accuracy (72%–75% vs 68%–69%) for identifying individuals who progressed to dementia compared to hippocampus and whole brain volume. The adjusted odds ratio for progression to dementia was 6.1 (95% CI: 1.6–23.8) and 4.1 (95% CI: 1.2–14.2) higher with abnormal CCM measures, but was not significant for abnormal brain volume. INTERPRETATION: Abnormal CCM measures have a higher prognostic accuracy than brain volumetry for predicting progression from MCI to dementia. Further work is required to validate the predictive ability of CCM compared to other established biomarkers of dementia. |
format | Online Article Text |
id | pubmed-10109317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101093172023-04-18 Corneal nerve loss predicts dementia in patients with mild cognitive impairment Ponirakis, Georgios Al Hamad, Hanadi Omar, Dunya A. M. Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Chandran, Mani Gadelseed, Masharig Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Tosino, Rhia Mahfoud, Ziyad R. Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Refaee, Mahmoud A. Thodi, Noushad Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. Ann Clin Transl Neurol Research Articles OBJECTIVES: This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). METHODS: Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia. RESULTS: Of 107 participants with MCI aged 68.4 ± 7.7 years, 33 (30.8%) progressed to dementia over 2.6‐years of follow‐up. Compared to participants with NCI (n = 12), participants who remained with MCI (n = 74) or progressed to dementia had lower corneal nerve measures (p < 0.0001). Progressors had lower corneal nerve measures, hippocampal, and whole brain volume (all p < 0.0001). However, CCM had a higher prognostic accuracy (72%–75% vs 68%–69%) for identifying individuals who progressed to dementia compared to hippocampus and whole brain volume. The adjusted odds ratio for progression to dementia was 6.1 (95% CI: 1.6–23.8) and 4.1 (95% CI: 1.2–14.2) higher with abnormal CCM measures, but was not significant for abnormal brain volume. INTERPRETATION: Abnormal CCM measures have a higher prognostic accuracy than brain volumetry for predicting progression from MCI to dementia. Further work is required to validate the predictive ability of CCM compared to other established biomarkers of dementia. John Wiley and Sons Inc. 2023-02-28 /pmc/articles/PMC10109317/ /pubmed/36852724 http://dx.doi.org/10.1002/acn3.51747 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Ponirakis, Georgios Al Hamad, Hanadi Omar, Dunya A. M. Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Chandran, Mani Gadelseed, Masharig Elsotouhy, Ahmed Ramadan, Marwan Gawhale, Priya V. Elorrabi, Marwa Tosino, Rhia Mahfoud, Ziyad R. Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Refaee, Mahmoud A. Thodi, Noushad Own, Ahmed Shuaib, Ashfaq Malik, Rayaz A. Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
title | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
title_full | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
title_fullStr | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
title_full_unstemmed | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
title_short | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
title_sort | corneal nerve loss predicts dementia in patients with mild cognitive impairment |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109317/ https://www.ncbi.nlm.nih.gov/pubmed/36852724 http://dx.doi.org/10.1002/acn3.51747 |
work_keys_str_mv | AT ponirakisgeorgios cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT alhamadhanadi cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT omardunyaam cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT petropoulosioannisn cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT khanadnan cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT gadhoda cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT chandranmani cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT gadelseedmasharig cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT elsotouhyahmed cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT ramadanmarwan cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT gawhalepriyav cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT elorrabimarwa cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT tosinorhia cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT mahfoudziyadr cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT khanshafi cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT manikothpravija cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT abdelrahimyasminhm cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT refaeemahmouda cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT thodinoushad cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT ownahmed cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT shuaibashfaq cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment AT malikrayaza cornealnervelosspredictsdementiainpatientswithmildcognitiveimpairment |