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P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing
BACKGROUND: Overnight studies are used to diagnose sleep disordered breathing (SDB), however the minimum artefact-free recording time (AFRT) has not been established in children. AIM: To determine the impact of AFRT on SDB diagnoses. METHODS: Patients attended overnight cardiorespiratory polygraphy/...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109378/ http://dx.doi.org/10.1093/sleepadvances/zpab014.110 |
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author | Knowles, A Stibalova, M Gajaweera, H Hill, C Evans, H |
author_facet | Knowles, A Stibalova, M Gajaweera, H Hill, C Evans, H |
author_sort | Knowles, A |
collection | PubMed |
description | BACKGROUND: Overnight studies are used to diagnose sleep disordered breathing (SDB), however the minimum artefact-free recording time (AFRT) has not been established in children. AIM: To determine the impact of AFRT on SDB diagnoses. METHODS: Patients attended overnight cardiorespiratory polygraphy/polysomnography, alongside pulse oximetry sleep studies. Respiratory parameter reports were generated using the first 4, 5, 6 and 7 hours of AFRT. Predetermined clinically relevant cut-off (CRCO) values were defined: Obstructive AHI (OAHI; CRCO≥2); Central Apnoea-Hypopnoea Index (CAHI; CRCO≥5); 3% Oxygen Desaturation Index (ODI3%; CRCO≥6); 4% Oxygen Desaturation Index (ODI4%; CRCO≥4). Studies crossing CRCO across different AFRTs were described as ‘Cases of Change’ (COC). Receiver operating characteristic (ROC) curves determined ranges at 4 hours which predicted COC across subsequent AFRTs. RESULTS: 137 children (0.39–17.98 years) were consecutively recruited. Mean OAHI, CAHI, ODI3% and ODI4% were 1.54 (σ=2.66), 1.56 (σ=3.43), 5.21 (σ=6.53) and 2.77 (σ=4.42) respectively. For children achieving 7 hours AFRT (n=103), COC from 4 hours were: OAHI≥2 =9.7% (10/103); CAHI≥5 =2.9% (3/103); ODI3%≥6 =3.7% (4/109); ODI4%≥4 =1.8% (2/109). For OAHI≥2, optimal points on ROC curves for predicting COC provided a range of 0.875 (AUC= 0.733; 50% sensitivity; 93% specificity) - 3.125 (AUC= 0.968; 100% sensitivity; 81% specificity). CONCLUSION: Four hours AFRT yields diagnostic results in > 90% cases when commonly used cut-off criteria are applied. For OSA, ranges at 4 hours within which diagnostic change is most likely with longer periods of AFRT are provided. Consideration should be given to repeating short studies where values lie within these ranges. |
format | Online Article Text |
id | pubmed-10109378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101093782023-05-15 P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing Knowles, A Stibalova, M Gajaweera, H Hill, C Evans, H Sleep Adv Poster Presentations BACKGROUND: Overnight studies are used to diagnose sleep disordered breathing (SDB), however the minimum artefact-free recording time (AFRT) has not been established in children. AIM: To determine the impact of AFRT on SDB diagnoses. METHODS: Patients attended overnight cardiorespiratory polygraphy/polysomnography, alongside pulse oximetry sleep studies. Respiratory parameter reports were generated using the first 4, 5, 6 and 7 hours of AFRT. Predetermined clinically relevant cut-off (CRCO) values were defined: Obstructive AHI (OAHI; CRCO≥2); Central Apnoea-Hypopnoea Index (CAHI; CRCO≥5); 3% Oxygen Desaturation Index (ODI3%; CRCO≥6); 4% Oxygen Desaturation Index (ODI4%; CRCO≥4). Studies crossing CRCO across different AFRTs were described as ‘Cases of Change’ (COC). Receiver operating characteristic (ROC) curves determined ranges at 4 hours which predicted COC across subsequent AFRTs. RESULTS: 137 children (0.39–17.98 years) were consecutively recruited. Mean OAHI, CAHI, ODI3% and ODI4% were 1.54 (σ=2.66), 1.56 (σ=3.43), 5.21 (σ=6.53) and 2.77 (σ=4.42) respectively. For children achieving 7 hours AFRT (n=103), COC from 4 hours were: OAHI≥2 =9.7% (10/103); CAHI≥5 =2.9% (3/103); ODI3%≥6 =3.7% (4/109); ODI4%≥4 =1.8% (2/109). For OAHI≥2, optimal points on ROC curves for predicting COC provided a range of 0.875 (AUC= 0.733; 50% sensitivity; 93% specificity) - 3.125 (AUC= 0.968; 100% sensitivity; 81% specificity). CONCLUSION: Four hours AFRT yields diagnostic results in > 90% cases when commonly used cut-off criteria are applied. For OSA, ranges at 4 hours within which diagnostic change is most likely with longer periods of AFRT are provided. Consideration should be given to repeating short studies where values lie within these ranges. Oxford University Press 2021-10-07 /pmc/articles/PMC10109378/ http://dx.doi.org/10.1093/sleepadvances/zpab014.110 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Sleep Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Poster Presentations Knowles, A Stibalova, M Gajaweera, H Hill, C Evans, H P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing |
title | P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing |
title_full | P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing |
title_fullStr | P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing |
title_full_unstemmed | P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing |
title_short | P064 The Impact of Artefact-free Recording Time on the Diagnosis of Sleep Disordered Breathing |
title_sort | p064 the impact of artefact-free recording time on the diagnosis of sleep disordered breathing |
topic | Poster Presentations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109378/ http://dx.doi.org/10.1093/sleepadvances/zpab014.110 |
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