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Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study

BACKGROUND: We aimed to measure the seroprevalences and levels of anti-SARS-CoV-2 IgG in children, unvaccinated and vaccinated adults in five districts of Bangladesh and thus, investigate the association of seroprevalence and anti-SARS-CoV-2 IgG level with respect to different attributes of study pa...

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Autores principales: Saba, Abdullah Al, Sayem, Mohammad, Rimon, Razoan Al, Sanyal, Mousumi, Chakraborty, Sajib, Rahman, Md Arifur, Rahman, Md Mizanur, Nabi, A.H.M. Nurun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110279/
https://www.ncbi.nlm.nih.gov/pubmed/37119719
http://dx.doi.org/10.1016/j.jiph.2023.04.013
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author Saba, Abdullah Al
Sayem, Mohammad
Rimon, Razoan Al
Sanyal, Mousumi
Chakraborty, Sajib
Rahman, Md Arifur
Rahman, Md Mizanur
Nabi, A.H.M. Nurun
author_facet Saba, Abdullah Al
Sayem, Mohammad
Rimon, Razoan Al
Sanyal, Mousumi
Chakraborty, Sajib
Rahman, Md Arifur
Rahman, Md Mizanur
Nabi, A.H.M. Nurun
author_sort Saba, Abdullah Al
collection PubMed
description BACKGROUND: We aimed to measure the seroprevalences and levels of anti-SARS-CoV-2 IgG in children, unvaccinated and vaccinated adults in five districts of Bangladesh and thus, investigate the association of seroprevalence and anti-SARS-CoV-2 IgG level with respect to different attributes of study participants. METHODS: In the present study, the seroprevalences and levels of plasma anti-SARS-CoV-2 IgG were measured in children (n = 202), unvaccinated adults (n = 112), and vaccinated adults (n = 439) using quantitative ELISA. RESULTS: The overall seroprevalence in the three groups of the study participants were 58.3% (90%CrI: 52.3–64.2%), 62.2% (90%CrI: 54.4–70.0%) and 90.7% (90%CrI: 88.3–92.9%), respectively. Multivariate logistic and linear regression revealed no significant association of seropositivity and levels of anti-SARS-CoV-2 IgG with the baseline characteristics of the children. AB blood group (vs A; aOR=0.21, 95% CI: 0.04–0.92, p = 0.04), O blood group (vs A; aOR=0.09, 95% CI: 0.02–0.32, p = 0.0004), BMI (aOR=1.61, 95% CI: 1.14-2.37, p = 0.01) and overweight obesity status (vs normal, aOR=0.12, 95% CI: 0.02-0.76, p = 0.03) were significantly associated with seropositivity in unvaccinated adults after adjusting for confounders. Age (p = 0.002) was significantly associated with anti-SARS-CoV-2 level in vaccinated adults after adjusting for confounders. Most of the children and unvaccinated adults belonged to the lower antibody response class which implicates the necessity of vaccination. CONCLUSION: This study portrays a better way of evaluating transmission of virus and gain a better understanding of the true extent of infection as illustrated by the high rates of seroprevalences in children and unvaccinated adults. The findings of this study depicted from the antibody response also suggest the importance of vaccination.
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spelling pubmed-101102792023-04-18 Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study Saba, Abdullah Al Sayem, Mohammad Rimon, Razoan Al Sanyal, Mousumi Chakraborty, Sajib Rahman, Md Arifur Rahman, Md Mizanur Nabi, A.H.M. Nurun J Infect Public Health Article BACKGROUND: We aimed to measure the seroprevalences and levels of anti-SARS-CoV-2 IgG in children, unvaccinated and vaccinated adults in five districts of Bangladesh and thus, investigate the association of seroprevalence and anti-SARS-CoV-2 IgG level with respect to different attributes of study participants. METHODS: In the present study, the seroprevalences and levels of plasma anti-SARS-CoV-2 IgG were measured in children (n = 202), unvaccinated adults (n = 112), and vaccinated adults (n = 439) using quantitative ELISA. RESULTS: The overall seroprevalence in the three groups of the study participants were 58.3% (90%CrI: 52.3–64.2%), 62.2% (90%CrI: 54.4–70.0%) and 90.7% (90%CrI: 88.3–92.9%), respectively. Multivariate logistic and linear regression revealed no significant association of seropositivity and levels of anti-SARS-CoV-2 IgG with the baseline characteristics of the children. AB blood group (vs A; aOR=0.21, 95% CI: 0.04–0.92, p = 0.04), O blood group (vs A; aOR=0.09, 95% CI: 0.02–0.32, p = 0.0004), BMI (aOR=1.61, 95% CI: 1.14-2.37, p = 0.01) and overweight obesity status (vs normal, aOR=0.12, 95% CI: 0.02-0.76, p = 0.03) were significantly associated with seropositivity in unvaccinated adults after adjusting for confounders. Age (p = 0.002) was significantly associated with anti-SARS-CoV-2 level in vaccinated adults after adjusting for confounders. Most of the children and unvaccinated adults belonged to the lower antibody response class which implicates the necessity of vaccination. CONCLUSION: This study portrays a better way of evaluating transmission of virus and gain a better understanding of the true extent of infection as illustrated by the high rates of seroprevalences in children and unvaccinated adults. The findings of this study depicted from the antibody response also suggest the importance of vaccination. The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2023-06 2023-04-17 /pmc/articles/PMC10110279/ /pubmed/37119719 http://dx.doi.org/10.1016/j.jiph.2023.04.013 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Saba, Abdullah Al
Sayem, Mohammad
Rimon, Razoan Al
Sanyal, Mousumi
Chakraborty, Sajib
Rahman, Md Arifur
Rahman, Md Mizanur
Nabi, A.H.M. Nurun
Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study
title Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study
title_full Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study
title_fullStr Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study
title_full_unstemmed Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study
title_short Evaluating the seroprevalence of SARS-CoV-2 IgG in five different districts of Bangladesh. A seroepidemiological study
title_sort evaluating the seroprevalence of sars-cov-2 igg in five different districts of bangladesh. a seroepidemiological study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110279/
https://www.ncbi.nlm.nih.gov/pubmed/37119719
http://dx.doi.org/10.1016/j.jiph.2023.04.013
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