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The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review
Matrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial diseases, including cancer. More specifically, the expression...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Georg Thieme Verlag KG
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110361/ https://www.ncbi.nlm.nih.gov/pubmed/37077369 http://dx.doi.org/10.1055/s-0043-1768166 |
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author | Kalali, Datis |
author_facet | Kalali, Datis |
author_sort | Kalali, Datis |
collection | PubMed |
description | Matrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial diseases, including cancer. More specifically, the expression of MMP-9 and polymorphisms of its gene have been found to be correlated with the formation and the invasiveness of different types of cancer. Hence, the latter gene can potentially be used both as a clinical genetic marker and a possible target in anticancer therapy. The present minireview explores the role of the MMP-9 gene in the process of tumor formation, growth, and metastasis and presents an overview of the polymorphisms of the gene associated with cancer as well as its regulation mechanisms, to provide an insight into the potential clinical applications. Nevertheless, further clinical trials and research are still required to reach more valuable conclusions for the clinical implications of the recent findings. |
format | Online Article Text |
id | pubmed-10110361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Georg Thieme Verlag KG |
record_format | MEDLINE/PubMed |
spelling | pubmed-101103612023-04-18 The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review Kalali, Datis Glob Med Genet Matrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial diseases, including cancer. More specifically, the expression of MMP-9 and polymorphisms of its gene have been found to be correlated with the formation and the invasiveness of different types of cancer. Hence, the latter gene can potentially be used both as a clinical genetic marker and a possible target in anticancer therapy. The present minireview explores the role of the MMP-9 gene in the process of tumor formation, growth, and metastasis and presents an overview of the polymorphisms of the gene associated with cancer as well as its regulation mechanisms, to provide an insight into the potential clinical applications. Nevertheless, further clinical trials and research are still required to reach more valuable conclusions for the clinical implications of the recent findings. Georg Thieme Verlag KG 2023-04-17 /pmc/articles/PMC10110361/ /pubmed/37077369 http://dx.doi.org/10.1055/s-0043-1768166 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Kalali, Datis The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review |
title |
The Role of the
Matrix Metalloproteinase-9
Gene in Tumor Development and Metastasis: A Narrative Review
|
title_full |
The Role of the
Matrix Metalloproteinase-9
Gene in Tumor Development and Metastasis: A Narrative Review
|
title_fullStr |
The Role of the
Matrix Metalloproteinase-9
Gene in Tumor Development and Metastasis: A Narrative Review
|
title_full_unstemmed |
The Role of the
Matrix Metalloproteinase-9
Gene in Tumor Development and Metastasis: A Narrative Review
|
title_short |
The Role of the
Matrix Metalloproteinase-9
Gene in Tumor Development and Metastasis: A Narrative Review
|
title_sort | role of the
matrix metalloproteinase-9
gene in tumor development and metastasis: a narrative review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110361/ https://www.ncbi.nlm.nih.gov/pubmed/37077369 http://dx.doi.org/10.1055/s-0043-1768166 |
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