Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth

Growth factors secreted by stromal fibroblasts regulate the intestinal epithelium. Stroma-derived epidermal growth factor (EGF) family ligands are implicated in epithelial regeneration and tumorigenesis, but their specific contributions and associated mechanisms remain unclear. Here, we use primary...

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Detalles Bibliográficos
Autores principales: Lemmetyinen, Toni T., Viitala, Emma W., Wartiovaara, Linnea, Kaprio, Tuomas, Hagström, Jaana, Haglund, Caj, Katajisto, Pekka, Wang, Timothy C., Domènech-Moreno, Eva, Ollila, Saara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110400/
https://www.ncbi.nlm.nih.gov/pubmed/36912192
http://dx.doi.org/10.1242/dmm.049692

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