A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer

Elevated Ras signalling is highly prevalent in human cancer; however, targeting Ras-driven cancers with Ras pathway inhibitors often leads to undesirable side effects and to drug resistance. Thus, identifying compounds that synergise with Ras pathway inhibitors would enable lower doses of the Ras pa...

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Detalles Bibliográficos
Autores principales: La Marca, John E., Ely, Robert W., Diepstraten, Sarah T., Burke, Peter, Kelly, Gemma L., Humbert, Patrick O., Richardson, Helena E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110402/
https://www.ncbi.nlm.nih.gov/pubmed/36861754
http://dx.doi.org/10.1242/dmm.049769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110402/
https://www.ncbi.nlm.nih.gov/pubmed/36861754
http://dx.doi.org/10.1242/dmm.049769

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