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A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer
Elevated Ras signalling is highly prevalent in human cancer; however, targeting Ras-driven cancers with Ras pathway inhibitors often leads to undesirable side effects and to drug resistance. Thus, identifying compounds that synergise with Ras pathway inhibitors would enable lower doses of the Ras pa...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110402/ https://www.ncbi.nlm.nih.gov/pubmed/36861754 http://dx.doi.org/10.1242/dmm.049769 |