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An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts

In vitro transcription (IVT) is a DNA-templated process for synthesizing long RNA transcripts, including messenger RNA (mRNA). For many research and commercial applications, IVT of mRNA is typically performed using bacteriophage T7 RNA polymerase (T7 RNAP) owing to its ability to produce full-length...

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Detalles Bibliográficos
Autores principales:	Dousis, Athanasios, Ravichandran, Kanchana, Hobert, Elissa M., Moore, Melissa J., Rabideau, Amy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110463/ https://www.ncbi.nlm.nih.gov/pubmed/36357718 http://dx.doi.org/10.1038/s41587-022-01525-6

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