Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer

Our recent work has shown that DCAF1 (also known as VprBP) is overexpressed in colon cancer and phosphorylates histone H2AT120 to drive epigenetic gene inactivation and oncogenic transformation. We have extended these observations by investigating whether DCAF1 also phosphorylates non-histone protei...

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Detalles Bibliográficos
Autores principales: Ghate, Nikhil B., Kim, Sungmin, Shin, Yonghwan, Kim, Jinman, Doche, Michael, Valena, Scott, Situ, Alan, Kim, Sangnam, Rhie, Suhn K., Lenz, Heinz-Josef, Ulmer, Tobias S., Mumenthaler, Shannon M., An, Woojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110550/
https://www.ncbi.nlm.nih.gov/pubmed/37069142
http://dx.doi.org/10.1038/s41467-023-37883-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110550/
https://www.ncbi.nlm.nih.gov/pubmed/37069142
http://dx.doi.org/10.1038/s41467-023-37883-1

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