Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported. To study the impact of intratumoral VHL heterogeneity observed in human ccRCC,...

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Detalles Bibliográficos
Autores principales: Hu, Junhui, Tan, Ping, Ishihara, Moe, Bayley, Nicholas A., Schokrpur, Shiruyeh, Reynoso, Jeremy G., Zhang, Yangjun, Lim, Raymond J., Dumitras, Camelia, Yang, Lu, Dubinett, Steven M., Jat, Parmjit S., Van Snick, Jacques, Huang, Jiaoti, Chin, Arnold I., Prins, Robert M., Graeber, Thomas G., Xu, Hua, Wu, Lily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110583/
https://www.ncbi.nlm.nih.gov/pubmed/37069149
http://dx.doi.org/10.1038/s41392-023-01362-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110583/
https://www.ncbi.nlm.nih.gov/pubmed/37069149
http://dx.doi.org/10.1038/s41392-023-01362-2

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