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The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates
Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson’s disease and the effect...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110608/ https://www.ncbi.nlm.nih.gov/pubmed/37069159 http://dx.doi.org/10.1038/s41531-023-00508-x |
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author | Lamoš, Martin Bočková, Martina Goldemundová, Sabina Baláž, Marek Chrastina, Jan Rektor, Ivan |
author_facet | Lamoš, Martin Bočková, Martina Goldemundová, Sabina Baláž, Marek Chrastina, Jan Rektor, Ivan |
author_sort | Lamoš, Martin |
collection | PubMed |
description | Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson’s disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson’s disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson’s disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS. |
format | Online Article Text |
id | pubmed-10110608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-101106082023-04-19 The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates Lamoš, Martin Bočková, Martina Goldemundová, Sabina Baláž, Marek Chrastina, Jan Rektor, Ivan NPJ Parkinsons Dis Article Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson’s disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson’s disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson’s disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS. Nature Publishing Group UK 2023-04-17 /pmc/articles/PMC10110608/ /pubmed/37069159 http://dx.doi.org/10.1038/s41531-023-00508-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lamoš, Martin Bočková, Martina Goldemundová, Sabina Baláž, Marek Chrastina, Jan Rektor, Ivan The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates |
title | The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates |
title_full | The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates |
title_fullStr | The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates |
title_full_unstemmed | The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates |
title_short | The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates |
title_sort | effect of deep brain stimulation in parkinson’s disease reflected in eeg microstates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110608/ https://www.ncbi.nlm.nih.gov/pubmed/37069159 http://dx.doi.org/10.1038/s41531-023-00508-x |
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