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The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates

Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson’s disease and the effect...

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Autores principales: Lamoš, Martin, Bočková, Martina, Goldemundová, Sabina, Baláž, Marek, Chrastina, Jan, Rektor, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110608/
https://www.ncbi.nlm.nih.gov/pubmed/37069159
http://dx.doi.org/10.1038/s41531-023-00508-x
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author Lamoš, Martin
Bočková, Martina
Goldemundová, Sabina
Baláž, Marek
Chrastina, Jan
Rektor, Ivan
author_facet Lamoš, Martin
Bočková, Martina
Goldemundová, Sabina
Baláž, Marek
Chrastina, Jan
Rektor, Ivan
author_sort Lamoš, Martin
collection PubMed
description Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson’s disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson’s disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson’s disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS.
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spelling pubmed-101106082023-04-19 The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates Lamoš, Martin Bočková, Martina Goldemundová, Sabina Baláž, Marek Chrastina, Jan Rektor, Ivan NPJ Parkinsons Dis Article Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson’s disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson’s disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson’s disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS. Nature Publishing Group UK 2023-04-17 /pmc/articles/PMC10110608/ /pubmed/37069159 http://dx.doi.org/10.1038/s41531-023-00508-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lamoš, Martin
Bočková, Martina
Goldemundová, Sabina
Baláž, Marek
Chrastina, Jan
Rektor, Ivan
The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates
title The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates
title_full The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates
title_fullStr The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates
title_full_unstemmed The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates
title_short The effect of deep brain stimulation in Parkinson’s disease reflected in EEG microstates
title_sort effect of deep brain stimulation in parkinson’s disease reflected in eeg microstates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110608/
https://www.ncbi.nlm.nih.gov/pubmed/37069159
http://dx.doi.org/10.1038/s41531-023-00508-x
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