PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat

Retrorsine is a hepatotoxic pyrrolizidine alkaloid (PA) found in herbal supplements and medicines, food and livestock feed. Dose-response studies enabling the derivation of a point of departure including a benchmark dose for risk assessment of retrorsine in humans and animals are not available. Addr...

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Detalles Bibliográficos
Autores principales: Lehmann, Anja, Geburek, Ina, These, Anja, Hessel-Pras, Stefanie, Hengstler, Jan G., Albrecht, Wiebke, Mielke, Hans, Müller-Graf, Christine, Yang, Xiaojing, Kloft, Charlotte, Hethey, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110657/
https://www.ncbi.nlm.nih.gov/pubmed/36906727
http://dx.doi.org/10.1007/s00204-023-03453-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110657/
https://www.ncbi.nlm.nih.gov/pubmed/36906727
http://dx.doi.org/10.1007/s00204-023-03453-z

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