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PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat

Retrorsine is a hepatotoxic pyrrolizidine alkaloid (PA) found in herbal supplements and medicines, food and livestock feed. Dose-response studies enabling the derivation of a point of departure including a benchmark dose for risk assessment of retrorsine in humans and animals are not available. Addr...

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Detalles Bibliográficos
Autores principales:	Lehmann, Anja, Geburek, Ina, These, Anja, Hessel-Pras, Stefanie, Hengstler, Jan G., Albrecht, Wiebke, Mielke, Hans, Müller-Graf, Christine, Yang, Xiaojing, Kloft, Charlotte, Hethey, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Toxicokinetics and Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110657/ https://www.ncbi.nlm.nih.gov/pubmed/36906727 http://dx.doi.org/10.1007/s00204-023-03453-z

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