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Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery

Pyrrolizidine alkaloids (PAs) occur as contaminants in plant-based foods and herbal medicines. Following metabolic activation by cytochrome P450 (CYP) enzymes, PAs induce DNA damage, hepatotoxicity and can cause liver cancer in rodents. There is ample evidence that the chemical structure of PAs dete...

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Detalles Bibliográficos
Autores principales:	Haas, Manuel, Wirachowski, Karina, Thibol, Lea, Küpper, Jan-Heiner, Schrenk, Dieter, Fahrer, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Genotoxicity and Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110667/ https://www.ncbi.nlm.nih.gov/pubmed/36928417 http://dx.doi.org/10.1007/s00204-023-03482-8

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