Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma

Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is highly expressed in many cancers and affects their occurrence and development. However, the effect of EIF4G1 on the prognosis, biological function and the relevant mechanism in lung squamous cell carcinoma (LSCC) is unclear. Through clin...

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Autores principales: Bai, Baoxin, Dong, Lin, Feng, Minghao, Zhang, Zhiwen, Lu, Ying, Xu, Zengguang, Liu, Yali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110680/
https://www.ncbi.nlm.nih.gov/pubmed/36897548
http://dx.doi.org/10.1007/s13577-023-00884-9
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author Bai, Baoxin
Dong, Lin
Feng, Minghao
Zhang, Zhiwen
Lu, Ying
Xu, Zengguang
Liu, Yali
author_facet Bai, Baoxin
Dong, Lin
Feng, Minghao
Zhang, Zhiwen
Lu, Ying
Xu, Zengguang
Liu, Yali
author_sort Bai, Baoxin
collection PubMed
description Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is highly expressed in many cancers and affects their occurrence and development. However, the effect of EIF4G1 on the prognosis, biological function and the relevant mechanism in lung squamous cell carcinoma (LSCC) is unclear. Through clinical cases, Cox’s proportional hazard model and Kaplan–Meier plotter survival analysis, we find the expression levels of EIF4G1 are dependent on age and clinical stage, high expression of EIF4G1 could be used to predict the overall survival of LSCC patients. LSCC cell line NCI-H1703, NCI-H226 and SK-MES-1infected with EIF4G1 siRNA are used to detect the function of EIF4G1 with cell proliferation and tumorigenesis in vivo and vitro. The data show that EIF4G1 promotes tumor cell proliferation and the G1/S transition of cell cycle in LSCC, then the biological function of LSCC is effected by the AKT/mTOR pathway. Above all, these results have demonstrated that EIF4G1 promotes LSCC cell proliferation and may represent an indicator of prognosis in LSCC.
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spelling pubmed-101106802023-04-19 Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma Bai, Baoxin Dong, Lin Feng, Minghao Zhang, Zhiwen Lu, Ying Xu, Zengguang Liu, Yali Hum Cell Research Article Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is highly expressed in many cancers and affects their occurrence and development. However, the effect of EIF4G1 on the prognosis, biological function and the relevant mechanism in lung squamous cell carcinoma (LSCC) is unclear. Through clinical cases, Cox’s proportional hazard model and Kaplan–Meier plotter survival analysis, we find the expression levels of EIF4G1 are dependent on age and clinical stage, high expression of EIF4G1 could be used to predict the overall survival of LSCC patients. LSCC cell line NCI-H1703, NCI-H226 and SK-MES-1infected with EIF4G1 siRNA are used to detect the function of EIF4G1 with cell proliferation and tumorigenesis in vivo and vitro. The data show that EIF4G1 promotes tumor cell proliferation and the G1/S transition of cell cycle in LSCC, then the biological function of LSCC is effected by the AKT/mTOR pathway. Above all, these results have demonstrated that EIF4G1 promotes LSCC cell proliferation and may represent an indicator of prognosis in LSCC. Springer Nature Singapore 2023-03-10 2023 /pmc/articles/PMC10110680/ /pubmed/36897548 http://dx.doi.org/10.1007/s13577-023-00884-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Bai, Baoxin
Dong, Lin
Feng, Minghao
Zhang, Zhiwen
Lu, Ying
Xu, Zengguang
Liu, Yali
Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
title Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
title_full Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
title_fullStr Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
title_full_unstemmed Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
title_short Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
title_sort prognostic and functional roles of eif4g1 in lung squamous cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110680/
https://www.ncbi.nlm.nih.gov/pubmed/36897548
http://dx.doi.org/10.1007/s13577-023-00884-9
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