A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation

BACKGROUND: Chronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs). Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme of immune tolerance catalyzing the initial step of tryptophan degradation along the so-called l-kynurenine (l-kyn) pathway, tha...

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Detalles Bibliográficos
Autores principales: Mannarino, Massimo R., Bianconi, Vanessa, Scalisi, Giulia, Franceschini, Luca, Manni, Giorgia, Cucci, Alessia, Bagaglia, Francesco, Mencarelli, Giulia, Giglioni, Francesco, Ricciuti, Doriana, Figorilli, Filippo, Pieroni, Benedetta, Cosentini, Elena, Padiglioni, Eleonora, Colangelo, Cecilia, Fuchs, Dietmar, Puccetti, Paolo, Follenzi, Antonia, Pirro, Matteo, Gargaro, Marco, Fallarino, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110845/
https://www.ncbi.nlm.nih.gov/pubmed/37081894
http://dx.doi.org/10.3389/fimmu.2023.964660

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