Generation of a symmetrical trispecific NK cell engager based on a two-in-one antibody

To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of trispecific natural killer cell engagers based on a...

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Detalles Bibliográficos
Autores principales: Harwardt, Julia, Carrara, Stefania C., Bogen, Jan P., Schoenfeld, Katrin, Grzeschik, Julius, Hock, Björn, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110854/
https://www.ncbi.nlm.nih.gov/pubmed/37081888
http://dx.doi.org/10.3389/fimmu.2023.1170042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110854/
https://www.ncbi.nlm.nih.gov/pubmed/37081888
http://dx.doi.org/10.3389/fimmu.2023.1170042

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