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MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy

Background: T-type Ca(2+) channels (Ca(v)3) represent emerging therapeutic targets for a range of neurological disorders, including epilepsy and pain. To aid the development and optimisation of new therapeutics, there is a need to identify novel chemical entities which act at these ion channels. A n...

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Detalles Bibliográficos
Autores principales: Harman, Thomas, Udoh, Michael, McElroy, Dan L., Anderson, Lyndsey L., Kevin, Richard C., Banister, Samuel D., Ametovski, Adam, Markham, Jack, Bladen, Chris, Doohan, Peter T., Greba, Quentin, Laprairie, Robert B., Snutch, Terrance P., McGregor, Iain S., Howland, John G., Arnold, Jonathon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110893/
https://www.ncbi.nlm.nih.gov/pubmed/37082241
http://dx.doi.org/10.3389/fphys.2023.1086243

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